Document Detail

Usefulness of right ventricular isovolumic relaxation time in predicting systolic pulmonary artery pressure.
MedLine Citation:
PMID:  18490309     Owner:  NLM     Status:  MEDLINE    
AIMS: Systolic pulmonary artery pressure (sPAP) cannot always be assessed from Doppler-detected tricuspid regurgitation (TR), especially when sPAP is normal. The right ventricular isovolumic relaxation time (rIVRT) is related to sPAP, and assessment of rIVRT by tissular Doppler imaging (rIVRT') has recently been proposed as an alternative method for estimating sPAP in patients with pulmonary artery hypertension (PAH). We evaluated here its usefulness in everyday clinical practice. METHODS AND RESULTS: We conducted a prospective Doppler vs. catheterization study in 26 patients. TR was undetectable in 6 patients (32%) with normal sPAP and in one patient (14%) from those with PAH. rIVRT' was recordable in all patients. We found a strong correlation between rIVRT' and sPAP (r = 0.87; P < 0.0001). rIVRT' had a high sensitivity in detecting PAH, and a rIVRT' of 40 ms or less excluded PAH with a negative predictive value of 100%. We also found that a prolonged rIVRT' is not specific to PAH and that the rIVRT'-evaluated sPAP did not agree well with the catheter-evaluated value. CONCLUSION: Measurement of rIVRT' can help estimate sPAP in the absence of TR: A normal rIVRT' excludes PAH with a high negative predictive value. A prolonged rIVRT' is in favour of an elevated sPAP but cannot affirm it by itself.
Nicolas Bréchot; Laetitia Gambotti; Stéphane Lafitte; Raymond Roudaut
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2008-03-14
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  9     ISSN:  1532-2114     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-26     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  547-54     Citation Subset:  IM    
Department of Cardiology, University Hospital of Bordeaux-Pessac, Bordeaux-Pessac, France.
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MeSH Terms
Aged, 80 and over
Blood Pressure
Echocardiography, Doppler
Feasibility Studies
Heart Catheterization
Heart Ventricles / ultrasonography
Hypertension, Pulmonary / radiography*,  ultrasonography*
Middle Aged
Myocardial Contraction
Predictive Value of Tests
Prospective Studies
Pulmonary Artery
Reproducibility of Results
Ventricular Dysfunction, Right / radiography*,  ultrasonography*

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