| Usefulness of repeated recombinant human thyrotropin (rh-TSH) stimulated thyroglobulin test in the post-surgical follow-up of very low-risk patients with differentiated thyroid carcinoma. | |
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MedLine Citation:
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PMID: 22067268 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The European Thyroid Association (ETA) and the American Thyroid Association (ATA) guidelines identify subgroups of patients affected by thyroid carcinoma in whom, due to a low risk of recurrence, radioiodine ablation is not indicated. These patients, are referred to as "very low risk" according to the ETA consensus and "low risk" patients according to the ATA guidelines. The recommended post-surgical follow-up of these patients is based upon periodical measurements of serum Tg on levothyroxine therapy and neck ultrasound (US). Aim: To evaluate the usefulness of rh-TSH Tg test and its repetition 2-3 years afterwards in very low risk patients. Materials and Methods: We consecutively enrolled 32 patients with undetectable anti-Tg antibodies. Basal serum Tg levels was undetectable in all patients. Results: Following rh-TSH serum Tg remained undetectable in 23 (71.9%) patients (UP) and was >1.0 ng/ml in 9 (DP). US and WBS, revealed lymph node metastasis in 4/9 DP patients. A second rh-TSH stimulation test (36.9±3.5 months later) was performed in all UP and in five DP patients without proven recurrences. All the UP and 4/5 formerly DP patients showed undetectable Tg stimulation. Conclusions: Our results suggest that rhTSH Tg test may be helpful in very low-risk patients, given its ability to differentiate those who may be considered "free of disease" from those who require further investigation and treatment. Repeated rhTSH Tg tests may be indicated only in patients with detectable serum Tg at prior stimulation testing. |
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Authors:
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C Cappelli; M Rotondi; I Pirola; E De Martino; E Gandossi; B Agosti; E Agabiti Rosei; L Chiovato; M Castellano |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medical and Surgical Sciences, Internal Medicine and Endocrinology Unit, University of Brescia, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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