Document Detail

Usefulness of quantitative echocardiographic techniques to predict recovery of regional and global left ventricular function after acute myocardial infarction.
MedLine Citation:
PMID:  12586250     Owner:  NLM     Status:  MEDLINE    
The left ventricular response to dobutamine may be quantified using tissue Doppler measurement of myocardial velocity or displacement or 3-dimensional echocardiography to measure ventricular volume and ejection fraction. This study sought to explore the accuracy of these methods for predicting segmental and global responses to therapy. Standard dobutamine and 3-dimensional echocardiography were performed in 92 consecutive patients with abnormal left ventricular function at rest. Recovery of function was defined by comparison with follow-up echocardiography at rest 5 months later. Segments that showed improved regional function at follow-up showed a higher increment in peak tissue Doppler velocity with dobutamine therapy than in nonviable segments (1.2 +/- 0.4 vs 0.3 +/- 0.2 cm/s, p = 0.001). Similarly, patients who showed a >5% improvement of ejection fraction at follow-up showed a greater displacement response to dobutamine (6.9 +/- 3.2 vs 2.1 +/- 2.3 mm, p = 0.001), as well as a higher rate of ejection fraction response to dobutamine (9 +/- 3% vs 2 +/- 2%, p = 0.001). The optimal cutoff values for predicting subsequent recovery of function at rest were an increment of peak velocity >1 cm/s, >5 mm of displacement, and a >5% improvement of ejection fraction with low-dose dobutamine.
Peter Cain; Vincent Khoury; Leanne Short; Thomas H Marwick
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  The American journal of cardiology     Volume:  91     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-14     Completed Date:  2003-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  AIM; IM    
University of Queensland, Brisbane, Australia.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary
Cardiotonic Agents / diagnostic use*
Coronary Artery Bypass
Coronary Circulation
Dobutamine / diagnostic use*
Echocardiography, Stress / methods*,  standards
Echocardiography, Three-Dimensional / methods*,  standards
Feasibility Studies
Follow-Up Studies
Myocardial Infarction / complications*,  therapy
Observer Variation
Predictive Value of Tests
ROC Curve
Recovery of Function*
Stroke Volume
Treatment Outcome
Ventricular Dysfunction, Left / etiology*,  physiopathology,  ultrasonography*
Reg. No./Substance:
0/Cardiotonic Agents; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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