Document Detail

Usefulness of polyethylene glycol solution with dimethylpolysiloxanes for bowel preparation before capsule endoscopy.
MedLine Citation:
PMID:  19793169     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Capsule endoscopy (CE) is widely used for diagnosing small intestinal diseases. In some cases, however, observation of target sites is very poor during CE because of residues etc. Herein we report the usefulness of a preparation comprised of polyethylene glycol solution (PEG) for CE. METHODS: This was a prospective, randomized, and single-blind study. Forty subjects, fasted for 12 h before CE, were randomized into two groups: 20 subjects in Group A were fasted only, whereas 20 in Group B received 1 liter (L) PEG with 200 mg dimethylpolysiloxane 3 h before CE. For evaluation, the observation period of the small intestine was divided into first and second halves. Subsequently, four investigators, blinded as to which group received the preparation, assessed the condition of the intestine using four rating scales in terms of 'residue' and 'intraluminal gas bubbles'. The effects of the preparation were statistically compared. RESULTS: CE images were better in Group B than in Group A with respect to 'intraluminal gas bubbles' (P = 0.0038) in the first half of the observation period, as well as residue (P = 0.0087) and intraluminal gas bubbles (P = 0.0011) in the second half. CONCLUSION: Bowel preparation using 1 L PEG with dimethylpolysiloxane 3 h before CE significantly reduced residue and intraluminal gas bubbles, and was considered to be a useful method for CE.
Sadaharu Nouda; Eijiro Morita; Mitsuyuki Murano; Akira Imoto; Takanori Kuramoto; Takuya Inoue; Naoko Murano; Ken Toshina; Eiji Umegaki; Kazuhide Higuchi
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-09-27
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  25     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-08     Completed Date:  2010-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  70-4     Citation Subset:  IM    
Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka, Japan.
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MeSH Terms
Aged, 80 and over
Antifoaming Agents / therapeutic use*
Capsule Endoscopy*
Dimethylpolysiloxanes / therapeutic use*
Gastrointestinal Agents / therapeutic use*
Intestinal Diseases / pathology*
Intestine, Small / pathology*
Middle Aged
Pharmaceutical Solutions
Polyethylene Glycols / therapeutic use*
Predictive Value of Tests
Prospective Studies
Single-Blind Method
Time Factors
Young Adult
Reg. No./Substance:
0/Antifoaming Agents; 0/Dimethylpolysiloxanes; 0/Gases; 0/Gastrointestinal Agents; 0/Pharmaceutical Solutions; 0/Polyethylene Glycols

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