Document Detail

Usefulness of plasma brain natriuretic peptide concentration for predicting subsequent left ventricular remodeling after coronary angioplasty in patients with acute myocardial infarction.
MedLine Citation:
PMID:  16893696     Owner:  NLM     Status:  MEDLINE    
To determine the relation between plasma brain natriuretic peptide (BNP) and remodeling in terms of infarct-related artery (IRA) patency, 106 patients with a first anterior wall acute myocardial infarction with a patent IRA at 1 month were studied. The IRA reoccluded at 6 months in 17 patients (reoccluded IRA) and was patent in 89 patients (patent IRA). The 2 groups did not differ with respect to clinical characteristics, hemodynamic variables, and left ventricular function at 1 month, except for left ventricular end-diastolic and systolic volumes, which were significantly greater in the reoccluded IRA group. Plasma BNP concentration in the reoccluded IRA group (336 +/- 288 pg/ml) was significantly higher than that in the patent IRA group (116 +/- 106 pg/ml) at 1 month. BNP concentration decreased significantly at 6 months in the 2 groups (reoccluded IRA vs patent IRA 152 +/- 162 vs 44 +/- 58 pg/ml, p <0.05). The increase in left ventricular volume from 1 to 6 months was significantly correlated with plasma BNP concentration at 1 month in the patent IRA group (r = 0.314, p < 0.01) and the reoccluded group (r = 0.634, p < 0.01). Linear regression analysis showed that the correlation between the 2 parameters in the 2 groups was similar. Based on stepwise multivariate linear regression analysis, only plasma BNP concentration was significantly correlated with the increase in left ventricular volume from 1 to 6 months in the 2 groups. In conclusion, these results suggest that plasma BNP concentration predicts left ventricular dilation independently of IRA patency.
Atsushi Hirayama; Hideo Kusuoka; Hiroyoshi Yamamoto; Yasushi Sakata; Masanori Asakura; Yoshiharu Higuchi; Hiroya Mizuno; Kazunori Kashiwase; Yasunori Ueda; Yuji Okuyama; Masatsugu Hori; Kazuhisa Kodama
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-06-19
Journal Detail:
Title:  The American journal of cardiology     Volume:  98     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-08     Completed Date:  2006-09-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  453-7     Citation Subset:  AIM; IM    
The Cardiovascular Division, Osaka Police Hospital, Osaka, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Biological Markers / blood
Coronary Angiography
Follow-Up Studies
Heart Ventricles / physiopathology,  radionuclide imaging
Immunoradiometric Assay
Middle Aged
Myocardial Infarction / blood,  diagnosis,  therapy*
Natriuretic Peptide, Brain / blood*
Stroke Volume
Tomography, Emission-Computed, Single-Photon
Ventricular Remodeling / physiology*
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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