Document Detail

Usefulness of an observational database to assess antiretroviral treatment trends in India.
MedLine Citation:
PMID:  16570679     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Human immunodeficiency virus (HIV) observational cohorts, which are established worldwide, support comparative studies across different regions. They have played an important role in developing international and country-specific HIV treatment and care guidelines. We describe the YRG CARE Chennai HIV observation database (YCHOD) and highlight its utility in monitoring trends in antiretroviral treatment use and HIV disease outcomes in India. METHODS: The baseline characteristics, time trends in antiretroviral treatment, trends in incidence of acquired immune deficiency syndrome (AIDS)-defining illness and mortality following the introduction of highly active antiretroviral therapy (HAART) in India were assessed using YCHOD. RESULTS: Till January 2005, 7647 HIV-positive patients had registered in YCHOD. A majority of the patients were men (69%) and had a mean age of 32 years. At baseline, 14% had an existing AIDS-defining illness. Among patients who required therapy by the WHO criteria, 14% initiated antiretroviral therapy (ART) in 1996 and 35% in 2000. Since the dramatic cost reduction of generic HAART in 2001, there has been an increase in the proportion of patients receiving ART to 57% in 2004. In patients who were started on HAART, the incidence of at least one AIDS-defining illness was 2% in 2001, and this decreased to 0.48% in 2004. CONCLUSION: We feel observational cohorts are useful as a surveillance tool for monitoring trends in treatment and disease progression. Standardized observational data collected systematically on HIV-infected individuals will help to assess the cost-effectiveness of ART and in planning ART strategies for India.
A J Cecelia; P Christybai; S Anand; K Jayakumar; T Gurunathan; P Vidya; S Solomon; N Kumarasamy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The National medical journal of India     Volume:  19     ISSN:  0970-258X     ISO Abbreviation:  Natl Med J India     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-03-30     Completed Date:  2006-05-16     Revised Date:  2009-07-30    
Medline Journal Info:
Nlm Unique ID:  8809315     Medline TA:  Natl Med J India     Country:  India    
Other Details:
Languages:  eng     Pagination:  14-7     Citation Subset:  IM    
YR Gaitonde Cente for AIDS Research and Education, Chennai, Tamil Nadu, India.
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MeSH Terms
AIDS-Related Opportunistic Infections / drug therapy*,  economics,  etiology
Anti-Retroviral Agents / therapeutic use*
Antiretroviral Therapy, Highly Active / utilization*
Databases as Topic*
Disease Progression
Guidelines as Topic
HIV Infections / complications,  drug therapy*,  economics
Hospitals, Special
India / epidemiology
Middle Aged
Population Surveillance / methods
Public Health Informatics*
Treatment Outcome
Reg. No./Substance:
0/Anti-Retroviral Agents

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