Document Detail

Usefulness of noninvasive MSCT coronary angiography as first-line imaging technique in patients with chest pain: initial clinical experience.
MedLine Citation:
PMID:  16004893     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Comparative studies with invasive coronary angiography (ICA) indicated a good sensitivity and specificity in the noninvasive detection of coronary artery disease (CAD) using Multi-slice spiral computed tomography coronary angiography (MS-CTA). The aim was to investigate the usefulness of MS-CTA as first-line imaging technique in patients (pts) with known or suspected CAD and low to intermediate probability of a severe coronary lesion. We report on our initial clinical experience using MS-CTA without compelled ICA. MATERIAL AND METHODS: One hundred thirty six patients with chest pain underwent MS-CTA on an outpatient basis (age 60+/-10, suspicion of CAD: n=95, suspicion of restenosis: n=24, after CABG: n=17). Based on the MS-CTA results, a recommendation concerning further diagnostics and therapy was given to each pt. A telephone interview was performed after 455+/-166 days to evaluate the further clinical course. RESULTS: Per pt, 8.2+/-2.7 coronary segments could be evaluated. Based on the MSCT results, the presence of flow-limiting stenoses was excluded in n=77 (57%) pts (group I). An additional ICA was recommended in n=59 (43%) pts (group II). An ICA had been performed in meantime in 27/136 (20%) pts, and could be avoided in the majority of pts. Nevertheless, 58/136 (42%) pts reported on improved clinical symptoms and 42/136 (31%) pts of improved quality of life. CONCLUSIONS: MS-CTA was found to be useful to evaluate the need and to reduce the total number of ICA in pts with unclear chest pain. It appears to be the first noninvasive modality, which might be used on a clinical routine basis in selected groups of pts.
Stephen Schroeder; Axel Kuettner; Torsten Beck; Andreas F Kopp; Christian Herdeg; Martin Heuschmid; Christof Burgstahler; Ludger Seipel; Claus D Claussen
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  102     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-11     Completed Date:  2006-01-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  469-75     Citation Subset:  IM    
Department of Internal Medicine, Division of Cardiology, Otfried-Mueller-Str. 10, 72076 Tuebingen, Germany.
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MeSH Terms
Angina Pectoris / diagnosis*,  physiopathology
Chest Pain / diagnosis*,  etiology
Coronary Angiography*
Coronary Artery Disease / diagnosis*,  physiopathology
Middle Aged
Prospective Studies
Risk Assessment
Risk Factors
Sensitivity and Specificity
Tomography, Spiral Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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