| Usefulness of a new tactile sensor for measurement of uterine cervical ripening in mice in a quantitative and noninvasive manner. | |
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MedLine Citation:
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PMID: 8828439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to establish a method with a new tactile sensor for determining in a quantitative and noninvasive manner the extent of uterine cervical ripening. STUDY DESIGN: We used a newly designed tactile sensor to measure the softness of the cervix in untreated nonpregnant, pregnant, parturient, and nursing mice and then on day 15 of gestation in pregnant mice treated with dehydroepiandrosterone sulfate or Escherichia coli lipopolysaccharide. Additionally, to elucidate the correlation between the extent of cervical softness and its morphologic changes, we observed microscopically the uterine cervices. RESULTS: The hardness of the murine cervix decreased with the progression of pregnancy and became minimal at delivery. We demonstrated for the first time with a tactile sensor for measuring hardness that dehydroepiandrosterone sulfate and lipopolysaccharide significantly decreased the stiffness of the murine cervix. These findings were supported by the morphologic observations on the cervices. CONCLUSIONS: These results show that the tactile sensor for measuring hardness makes it possible to determine the extent of cervical ripening quantitatively rather than qualitatively. We consider that cervical ripening determined objectively in this manner is a good parameter to predict the onset of preterm delivery. |
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Authors:
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N Kaga; Y Katsuki; C Kakinuma; M Obata; Y Shibutani; S Omata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 175 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-11-04 Completed Date: 1996-11-04 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 713-8 Citation Subset: AIM; IM |
Affiliation:
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Toxicology Laboratory, Mochida Pharmaceutical Co., Ltd., Shizuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cervix Uteri / anatomy & histology, physiology* Dehydroepiandrosterone Sulfate / pharmacology Electrodes Equipment and Supplies* Escherichia coli Female Gestational Age Labor, Obstetric / physiology* Lipopolysaccharides / pharmacology Mice Mice, Inbred C3H Pregnancy Touch Transducers |
| Chemical | |
Reg. No./Substance:
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0/Lipopolysaccharides; 651-48-9/Dehydroepiandrosterone Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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