Document Detail

Usefulness of a new proposed tissue Doppler imaging global function index in hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  16524389     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A global function index (GFI) derived from tissue Doppler imaging (TDI) has been proposed to improve the diagnosis of hypertrophic cardiomyopathy (HCM). We aimed to evaluate the usefulness of this index in a large selected HCM population. METHODS: GFI =[E/Ea]/Sa, was calculated at mitral annulus lateral and septal borders in 164 HCM patients and in 40 healthy volunteers. Group comparisons and correlations between GFI and other variables were performed. RESULTS: Of the 164 patients, 69 (42%) had a peak gradient >30 mmHg in the left ventricle outflow tract (LVOT). GFI (lateral or septal) was not normally distributed. There were differences among controls, obstructive HCM, and nonobstructive HCM (P < 0.0001), but significant overlap of GFI values were observed between groups. GFI was correlated to septal thickness (r = 0.44; P < 0.0001), left atrial diameter (r = 0.52; P < 0.0001), and LVOT gradient (r = 0.58; P < 0.0001). CONCLUSION: In a selected HCM population, GFI was limited by its asymmetrical distribution and significant overlap of values between groups. Further studies are necessary to verify the reliability of GFI in the clinical practice and its position among other tissue Doppler indices.
Aloir Q Araujo; Edmundo Arteaga; Barbara M Ianni; Vera Maria C Salemi; Felix J A Ramires; Afonso Y Matsumoto; Fabio Fernandes; Charles Mady
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  23     ISSN:  0742-2822     ISO Abbreviation:  Echocardiography     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-09     Completed Date:  2006-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-201     Citation Subset:  IM    
Heart Institute (INCOR), University of São Paulo Medical School, São Paulo, Brazil.
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MeSH Terms
Cardiomyopathy, Hypertrophic / physiopathology,  ultrasonography*
Case-Control Studies
Cross-Sectional Studies
Echocardiography, Doppler*
Middle Aged
Retrospective Studies
Statistics, Nonparametric

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