Document Detail

Usefulness of a morning routine EEG recording in patients with juvenile myoclonic epilepsy.
MedLine Citation:
PMID:  17851038     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate if a standard awake EEG recording in the morning is superior to afternoon awake EEG session in detecting generalized epileptiform discharges (GEDs) in patients with juvenile myoclonic epilepsy (JME). METHODS: The study group included 29 consecutive patients (23 women; mean age 22.3+/-6.3 years; age at onset of JME 15.4+/-3.4 years) with JME. Out of 29 patients 5 were untreated, 9 patients were treated with valproate, 8 with lamotrigine, 6 with levetiracetam and 1 patient with valproate plus phenobarbital. Two routine consecutive interictal EEG recordings were performed at 9a.m. and at 3p.m., respectively, while the subject was awake, on the same day after a a regular nocturnal sleep at own home. RESULTS: The morning EEG recording showed GEDs (i.e., generalized polispike and waves, photoparoxysmal response, or both). in 20/29 patients. In 15 of these 20 patients, the afternoon recording was normal and this difference was statistically significant (p < or = 0.001). Moreover, there was a striking reduction of GEDs in three of the remaining five patients. Nine/29 patients had both morning and afternoon EEG recording normal. CONCLUSIONS: The results of this study have illustrated a significant greater rate of detection of generalized epileptiform abnormalities by performing standard awake EEG in the morning in comparison with an afternoon session.
Angelo Labate; Roberta Ambrosio; Antonio Gambardella; Miriam Sturniolo; Franco Pucci; Aldo Quattrone
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Publication Detail:
Type:  Journal Article     Date:  2007-09-11
Journal Detail:
Title:  Epilepsy research     Volume:  77     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2008-01-02     Revised Date:  2008-04-23    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
Institute of Neurology, University Magna Graecia, Catanzaro, Italy.
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MeSH Terms
Age of Onset
Anticonvulsants / therapeutic use
Circadian Rhythm / physiology
Myoclonic Epilepsy, Juvenile / diagnosis*,  drug therapy
Photic Stimulation
Sleep Deprivation
Reg. No./Substance:
Comment In:
Epilepsy Res. 2008 Feb;78(2-3):244-5   [PMID:  18222065 ]

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