Document Detail


Usefulness of lowering low-density lipoprotein cholesterol to <70 mg/dl and usefulness of C-reactive protein in patient selection.
MedLine Citation:
PMID:  14609606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
C-reactive protein levels may identify patients likely to benefit from lowering low-density lipoprotein (LDL) cholesterol to ultra-low levels. We find that above-average C-reactive protein with statin therapy predicts failure of carotid intima-media thickness regression in those with currently defined optimal LDL cholesterol (<100 mg/dl) but not if LDL cholesterol is <70 mg/dl.
Authors:
Steven M Kent; Allen J Taylor
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  92     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-11     Completed Date:  2004-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1224-7     Citation Subset:  AIM; IM    
Affiliation:
Cardiology Service, Walter Reed Army Medical Center, Washington, DC 20307-5001, USA. steven.kent@na.amedd.army.mil
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MeSH Terms
Descriptor/Qualifier:
Aged
C-Reactive Protein / metabolism*
Carotid Arteries / drug effects
Carotid Artery Diseases / blood,  drug therapy*
Cholesterol, LDL / blood*
Female
Heptanoic Acids / therapeutic use*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Male
Middle Aged
Patient Selection*
Pravastatin / therapeutic use*
Pyrroles / therapeutic use*
Tunica Intima / drug effects
Tunica Media / drug effects
Chemical
Reg. No./Substance:
0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 81093-37-0/Pravastatin; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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