Document Detail


Usefulness of lipid apheresis in the treatment of familial hypercholesterolemia.
MedLine Citation:
PMID:  25386364     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Lipid apheresis is used to treat patients with severe hyperlipidemia by reducing low-density lipoprotein cholesterol (LDL-C). This study examines the effect of apheresis on the lipid panel and cardiac event rates before and after apheresis. An electronic health record screen of ambulatory patients identified 11 active patients undergoing lipid apheresis with 10/11 carrying a diagnosis of FH. Baseline demographics, pre- and postapheresis lipid levels, highest recorded LDL-C, cardiac events, current medications, and first apheresis treatment were recorded. Patients completed a questionnaire and self-reported risk factors and interest in alternative treatment. There were significant reductions in mean total cholesterol (-58.4%), LDL-C (-71.9%), triglycerides (-51%), high-density lipoprotein (HDL) cholesterol (-9.3%), and non-HDL (-68.2%) values. Thirty-four cardiac events were documented in 8 patients before apheresis, compared with 9 events in 5 patients after apheresis. Our survey showed a high prevalence of statin intolerance (64%), with the majority (90%) of participants indicating an interest in alternative treatment options. Our results have shown that lipid apheresis primary effect is a marked reduction in LDL-C cholesterol levels and may reduce the recurrence of cardiac events. Apheresis should be compared to the newer alternative treatment modalities in a randomized fashion due to patient interest in alternative options.
Authors:
Matthew Lui; Ross Garberich; Craig Strauss; Thomas Davin; Thomas Knickelbine
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Publication Detail:
Type:  Journal Article     Date:  2014-10-19
Journal Detail:
Title:  Journal of lipids     Volume:  2014     ISSN:  2090-3030     ISO Abbreviation:  J Lipids     Publication Date:  2014  
Date Detail:
Created Date:  2014-11-11     Completed Date:  2014-11-11     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  101553819     Medline TA:  J Lipids     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  864317     Citation Subset:  -    
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