Document Detail


Usefulness of itraconazole for sporotrichosis in Japan: study of three cases and literature comparison of therapeutic effects before and after release on the market.
MedLine Citation:
PMID:  16436341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Potassium iodide, itraconazole (ITCZ), and terbinafine are widely known as oral antifungal agents for the treatment of sporotrichosis. Although potassium iodide has been used as the antifungal agent of first choice in Japan due to its high efficacy, its use is not covered by the health insurance programs. In this report, we present the disease course of 3 patients with sporotrichosis in which ITCZ was remarkably effective. By reviewing cases reported in the past, we found sufficient therapeutic effects of ITCZ against sporotrichosis. We also conducted a simple comparison of the efficacy of ITCZ in clinical trials with that of its post-market release; finding the latter to be lower. This seems to be attributable to the problem of compliance or the administration method.
Authors:
Izumi Kikuchi; Kensuke Morimoto; Seiji Kawana; Hiroyuki Tanuma
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European journal of dermatology : EJD     Volume:  16     ISSN:  1167-1122     ISO Abbreviation:  Eur J Dermatol     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-01-26     Completed Date:  2006-05-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9206420     Medline TA:  Eur J Dermatol     Country:  France    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan. ogy@nms.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Antifungal Agents / therapeutic use*
Biopsy, Needle
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Approval
Female
Follow-Up Studies
Humans
Immunohistochemistry
Itraconazole / therapeutic use*
Japan
Male
Middle Aged
Product Surveillance, Postmarketing*
Risk Assessment
Severity of Illness Index
Sporotrichosis / drug therapy*,  pathology*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antifungal Agents; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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