Document Detail

Usefulness of high-sensitivity IL-6 measurement for clinical characterization of patients with coronary artery disease.
MedLine Citation:
PMID:  15900566     Owner:  NLM     Status:  MEDLINE    
Interleukin 6 (IL-6) may represent an early marker of inflammatory activation and may be useful to ameliorate risk stratification in patients with ischemic heart disease. The aim of this study was to verify the performance characteristics of an ultrasensitive immunoassay (Biosource International, Camarillo, CA) for high-sensitivity (hs)-IL-6 measurement in comparison with hs-R&D Systems (Abingdon, United Kingdom) and Immulite System (Diagnostic Products Corporation [DPC], Los Angeles, CA) methods in patients with ischemic heart disease. In addition, hs-C-reactive protein (hs-CRP) concentrations were measured, to evaluate the correlation with hs-IL-6 levels. We measured IL-6 and CRP serum levels in 39 patients with ischemic heart disease and in 12 controls. Out of the 39 patients studied, 13 were affected by unstable angina, 13 by post-acute myocardial infarction (AMI) unstable angina, and 13 by stable angina. The imprecision profile and functional sensitivity were performed measuring 9 different serum pools in 10 runs. The Biosource method had the best performance characteristics as compared to the others. Mean IL-6 level was higher in patients with unstable and post-AMI unstable angina with respect to controls. CRP levels were elevated in patients with post-AMI. In the whole population a high significant linear regression was observed between Biosource hs-IL-6 and hs-CRP serum levels. The Biosource method for IL-6 measurement is characterized by a high functional sensitivity that allows a better stratification of patients with ischemic heart disease.
Valter Lubrano; Franca Cocci; Debora Battaglia; Angela Papa; Paolo Marraccini; Gian Carlo Zucchelli
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  19     ISSN:  0887-8013     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-24     Completed Date:  2005-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  IM    
Copyright Information:
Copyright 2005 Wiley-Liss, Inc.
Institute of Clinical Physiology, CNR, Pisa, Italy.
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MeSH Terms
Angina, Unstable / diagnosis*
Biological Markers / blood
C-Reactive Protein / analysis
Coronary Artery Disease / diagnosis*
Immunoassay / methods*
Interleukin-6 / blood*
Middle Aged
Sensitivity and Specificity
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

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