Document Detail

Usefulness of high-frequency vascular ultrasound imaging and serum inflammatory markers to predict plaque rupture in patients with stable and unstable angina pectoris.
MedLine Citation:
PMID:  17950787     Owner:  NLM     Status:  MEDLINE    
It remains unclear what kind of morphologic and biochemical features best predict plaque rupture in patients with angina pectoris (AP). This study aimed to investigate whether combined high-frequency vascular ultrasound imaging and measurements of serum inflammatory biomarkers can predict coronary plaque ruptures in patients with AP. The study population consisted of 20 patients with stable AP and 40 patients with unstable AP. High-frequency vascular ultrasound imaging was performed in the 2 groups to measure intima-media thickness, the plaque acoustic density of the common carotid arteries, and the flow-mediated dilation of the brachial arteries. Serum lipid profile and inflammatory biomarkers were measured in all patients. Using intravascular ultrasound, a list of coronary imaging parameters was obtained. A multivariate logistic regression model was applied to calculate the odds ratio of each parameter to predict coronary plaque ruptures detected by intravascular ultrasound. Of 139 coronary artery plaques identified by intravascular ultrasound, 48 plaques (9 in stable AP and 39 in unstable AP) developed ruptures. Among measured parameters, the values of carotid intima-media thickness, coronary external elastic membrane area, plaque area, plaque burden, plaque eccentric index and remodeling index, serum high-sensitivity C-reactive protein, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 were significantly higher in unstable AP than in stable AP (p <0.05 to 0.01). Of these parameters, carotid intima-media thickness, serum high-sensitivity C-reactive protein, and the coronary remodeling index were found to be significant predictors of coronary plaque rupture, with odds ratios of 9.51 (95% confidence interval 1.29 to 21.81), 3.02 (95% confidence interval 1.01 to 7.65), and 0.01 (95% confidence interval 0.00 to 0.34), respectively. In conclusion, combined high-frequency ultrasound imaging of coronary and carotid arteries and measurements of serum inflammatory markers are able to predict coronary plaque ruptures in patients with AP.
Wen Qiang Chen; Mei Zhang; Xiao Ping Ji; Shi Fang Ding; Yu Xia Zhao; Yu Guo Chen; Cheng Zhang; Yun Zhang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-29
Journal Detail:
Title:  The American journal of cardiology     Volume:  100     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-20     Revised Date:  2008-06-24    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1341-6     Citation Subset:  AIM; IM    
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China.
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MeSH Terms
Angina Pectoris / blood*,  complications,  ultrasonography*
Angina, Unstable / blood,  ultrasonography*
Brachial Artery / ultrasonography
C-Reactive Protein / analysis*
Carotid Arteries / ultrasonography
Carotid Artery, Common / ultrasonography*
Coronary Vessels / chemistry,  pathology*
Intercellular Adhesion Molecule-1 / blood*
Logistic Models
Middle Aged
Odds Ratio
Predictive Value of Tests
Tunica Intima / pathology
Tunica Media / pathology
Ultrasonography, Interventional*
Vascular Cell Adhesion Molecule-1 / blood*
Reg. No./Substance:
0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein
Comment In:
Am J Cardiol. 2008 May 15;101(10):1519; author reply 1519   [PMID:  18471472 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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