| Usefulness of high-frequency analysis of signal-averaged surface electrocardiograms in acute myocardial infarction before and after coronary thrombolysis for assessing coronary reperfusion. | |
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MedLine Citation:
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PMID: 2122705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of late potentials on the signal-averaged electrocardiogram before and after coronary thrombolysis was studied in 54 patients with an acute myocardial infarction of less than or equal to 5 hours' duration and with an angiographically documented total occlusion of the infarct-related coronary artery on admission. A significant (p = 0.038) 50% relative reduction in the incidence of late potentials was observed in the group of 35 patients who underwent reperfusion: from 16 of 35 (46%) before to 8 of 35 (23%) at 120 minutes after the start of thrombolytic treatment. No significant reduction was seen in the 19 patients in whom thrombolysis was unsuccessful: from 8 of 19 (42%) before to 7 of 19 (37%) afterward. Despite successful recanalization, late potentials persisted or newly developed after thrombolytic therapy in 8 of 54 patients (15%). It is concluded that successful thrombolysis reduces the incidence of late potentials on the signal-averaged electrocardiogram but that the sensitivity and specificity of this finding are not high enough to allow reliable monitoring of coronary reperfusion at the bedside. |
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Authors:
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B Tranchesi; M Verstraete; F Van de Werf; C P de Albuquerque; B Caramelli; O C Gebara; W I Pereira; P Moffa; G Bellotti; F Pileggi |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 66 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1990-12-14 Completed Date: 1990-12-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1196-8 Citation Subset: AIM; IM |
Affiliation:
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Instituto do Coraçao (INCOR), University of Sao Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arrhythmias, Cardiac
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diagnosis* Electrocardiography / methods* Female Heart Conduction System / physiopathology Humans Male Middle Aged Myocardial Infarction / diagnosis, drug therapy* Myocardial Reperfusion* Recombinant Proteins / therapeutic use Sensitivity and Specificity Signal Processing, Computer-Assisted* Thrombolytic Therapy* Tissue Plasminogen Activator / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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