Document Detail


Usefulness of high-frequency analysis of signal-averaged surface electrocardiograms in acute myocardial infarction before and after coronary thrombolysis for assessing coronary reperfusion.
MedLine Citation:
PMID:  2122705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of late potentials on the signal-averaged electrocardiogram before and after coronary thrombolysis was studied in 54 patients with an acute myocardial infarction of less than or equal to 5 hours' duration and with an angiographically documented total occlusion of the infarct-related coronary artery on admission. A significant (p = 0.038) 50% relative reduction in the incidence of late potentials was observed in the group of 35 patients who underwent reperfusion: from 16 of 35 (46%) before to 8 of 35 (23%) at 120 minutes after the start of thrombolytic treatment. No significant reduction was seen in the 19 patients in whom thrombolysis was unsuccessful: from 8 of 19 (42%) before to 7 of 19 (37%) afterward. Despite successful recanalization, late potentials persisted or newly developed after thrombolytic therapy in 8 of 54 patients (15%). It is concluded that successful thrombolysis reduces the incidence of late potentials on the signal-averaged electrocardiogram but that the sensitivity and specificity of this finding are not high enough to allow reliable monitoring of coronary reperfusion at the bedside.
Authors:
B Tranchesi; M Verstraete; F Van de Werf; C P de Albuquerque; B Caramelli; O C Gebara; W I Pereira; P Moffa; G Bellotti; F Pileggi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  66     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-14     Completed Date:  1990-12-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1196-8     Citation Subset:  AIM; IM    
Affiliation:
Instituto do Coraçao (INCOR), University of Sao Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Arrhythmias, Cardiac / diagnosis*
Electrocardiography / methods*
Female
Heart Conduction System / physiopathology
Humans
Male
Middle Aged
Myocardial Infarction / diagnosis,  drug therapy*
Myocardial Reperfusion*
Recombinant Proteins / therapeutic use
Sensitivity and Specificity
Signal Processing, Computer-Assisted*
Thrombolytic Therapy*
Tissue Plasminogen Activator / therapeutic use*
Chemical
Reg. No./Substance:
0/Recombinant Proteins; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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