| Usefulness of high b-value diffusion-weighted MRI in the diagnosis of Creutzfeldt-Jakob disease. | |
| | |
MedLine Citation:
|
PMID: 21345540 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: current diagnostic criteria of probable Creutzfeldt-Jakob disease (CJD) include a combination of clinical, EEG and analytic data. Recent data indicate that brain MRI including fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging (DWI) sequences can be a valid and reliable tool for the diagnosis of CJD. We describe our experience with high b-value (3000s/mm(2)) diffusion-weighted imaging (DWI) in patients with probable or definite CJD and compare it with standard b-value (1000s/mm(2)) DWI. METHODS: we performed a retrospective analysis of patients admitted to our Hospital Service between 2002 and 2008 with a final diagnosis of probable or definite CJD. Patients were examined using either a 1.5 Tesla or a 3 Tesla MRI. The MRI protocol included T1-weigthed spin-echo sequences, T2-weighted fast spin-echo, FLAIR and DWI sequences with high b-value and standard b-value. RESULTS: during the study period there were 7 patients with probable or definite CJD. Only 3 patients (43%) showed changes on FLAIR sequence consistent with CJD. All the cases were detected with high b-value DWI, including 2 cases (28%) that would have been missed using standard b-value (1000s/mm(2)) DWI. In all the patients the changes were more conspicuous and extensive at high b-value DWI (b=3000s/mm(2)). CONCLUSION: our data indicate that high b-value DWI may improve the sensitivity of brain MRI for the diagnosis of CJD, allowing the detection of some cases that would have been overlooked by conventional sequences. |
| | |
Authors:
|
E Riva-Amarante; A Jiménez-Huete; R Toledano; M Calero; J Alvarez-Linera; J Escribano; M J Sánchez Migallón; O Franch |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-21 |
Journal Detail:
|
Title: Neurologia (Barcelona, Spain) Volume: - ISSN: 0213-4853 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9005460 Medline TA: Neurologia Country: - |
Other Details:
|
Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010 Sociedad Española de Neurología. Published by Elsevier Espana. All rights reserved. |
Affiliation:
|
Servicio de Neurología, Hospital Ruber Internacional, Madrid, España. |
Vernacular Title:
|
Utilidad de la resonancia magnética cerebral con secuencia de difusión y valor b alto en el diagnóstico de la enfermedad de Creutzfeldt-Jakob. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Usefulness of short tests in dementia screening.
Next Document: Movement disorders identified in patients with intracranial tuberculomas.