Document Detail

Usefulness of helium-oxygen mixtures in the treatment of mechanically ventilated patients.
MedLine Citation:
PMID:  12548029     Owner:  NLM     Status:  MEDLINE    
The density of helium is markedly lower than that of air or any of its components, leading to a substantial decrease in airway resistance to flow when it is inhaled. In mechanically ventilated patients with obstructive airway disease, replacing the usual air-oxygen mixture with helium-oxygen has been shown to reduce dynamic hyperinflation and intrinsic positive end-expiratory pressure; to decrease lung inflation pressures, respiratory acidosis, and work of breathing; and to improve arterial blood gases. Aerosol delivery to distal airways is enhanced with helium-oxygen. Preliminary data also suggest that the use of helium-oxygen could be a valuable approach to decrease postextubation respiratory distress. However, interference with ventilator function and added costs are two major disadvantages of helium-oxygen. Hence, before its widespread use in mechanically ventilated patients can be recommended, studies are needed to determine whether these favorable short-term effects can influence patient outcome.
Philippe Jolliet; Didier Tassaux
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in critical care     Volume:  9     ISSN:  1070-5295     ISO Abbreviation:  Curr Opin Crit Care     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-27     Completed Date:  2003-05-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9504454     Medline TA:  Curr Opin Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-50     Citation Subset:  IM    
Divisions of Medical Intensive Care and Anesthesiology, University Hospital, Geneva, Switzerland.
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MeSH Terms
Anoxia / physiopathology*
Helium / therapeutic use*
Oxygen / therapeutic use*
Pulmonary Disease, Chronic Obstructive / physiopathology,  therapy
Respiration, Artificial*
Respiratory Mechanics*
Respiratory Tract Diseases / physiopathology,  therapy*
Tidal Volume
Reg. No./Substance:
58933-55-4/heliox; 7440-59-7/Helium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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