| Usefulness of glycated albumin as an indicator of glycemic control status in patients with hemolytic anemia. | |
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MedLine Citation:
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PMID: 20965159 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: In patients with hemolytic anemia (HA), glycated hemoglobin (HbA(1C)) presents lower values in relation to glycemia because the lifespan of erythrocytes is shortened, whereas glycated albumin (GA) is not affected. In the present study, we examined the usefulness of GA as an indicator of glycemic control status in patients with HA. METHODS: We enrolled 21 patients with HA. A total of 202 patients with type 2 diabetes mellitus (T2DM) without complications were used as controls. RESULTS: We identified a significant correlation between GA and HbA(1C) in the patients with HA. However, in a comparison between the patients with HA and those with T2DM, the regression line showed a leftward shift in the former group. There was a significant positive correlation between hemoglobin (Hb) and HbA(1C) in the patients with HA (R=0.541, p=0.025), although there was no significant correlation between Hb and GA. There was an inverse correlation between Hb levels and GA/HbA(1C) ratio (R=-0.710, p=0.001). The measured HbA(1C) levels were lower than the HbA(1C) levels estimated from mean plasma glucose levels, whereas the GA/3 levels were close to the estimated HbA(1C) levels. CONCLUSIONS: GA is a useful indicator of glycemic control status in patients with HA. |
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Authors:
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Masafumi Koga; Kunihiko Hashimoto; Jun Murai; Hiroshi Saito; Mikio Mukai; Kazuhiro Ikegame; Hiroyasu Ogawa; Soji Kasayama |
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Publication Detail:
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Type: Journal Article Date: 2010-10-18 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 412 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 253-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Kinki Central Hospital, Kuruma-zuka 3-1, Itami, Hyogo 664-8533, Japan. koga_m@kich.itami.hyogo.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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