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Usefulness of glycated albumin as an indicator of glycemic control status in patients with hemolytic anemia.
MedLine Citation:
PMID:  20965159     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: In patients with hemolytic anemia (HA), glycated hemoglobin (HbA(1C)) presents lower values in relation to glycemia because the lifespan of erythrocytes is shortened, whereas glycated albumin (GA) is not affected. In the present study, we examined the usefulness of GA as an indicator of glycemic control status in patients with HA.
METHODS: We enrolled 21 patients with HA. A total of 202 patients with type 2 diabetes mellitus (T2DM) without complications were used as controls.
RESULTS: We identified a significant correlation between GA and HbA(1C) in the patients with HA. However, in a comparison between the patients with HA and those with T2DM, the regression line showed a leftward shift in the former group. There was a significant positive correlation between hemoglobin (Hb) and HbA(1C) in the patients with HA (R=0.541, p=0.025), although there was no significant correlation between Hb and GA. There was an inverse correlation between Hb levels and GA/HbA(1C) ratio (R=-0.710, p=0.001). The measured HbA(1C) levels were lower than the HbA(1C) levels estimated from mean plasma glucose levels, whereas the GA/3 levels were close to the estimated HbA(1C) levels.
CONCLUSIONS: GA is a useful indicator of glycemic control status in patients with HA.
Authors:
Masafumi Koga; Kunihiko Hashimoto; Jun Murai; Hiroshi Saito; Mikio Mukai; Kazuhiro Ikegame; Hiroyasu Ogawa; Soji Kasayama
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Publication Detail:
Type:  Journal Article     Date:  2010-10-18
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  412     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  253-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Internal Medicine, Kinki Central Hospital, Kuruma-zuka 3-1, Itami, Hyogo 664-8533, Japan. koga_m@kich.itami.hyogo.jp
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