Document Detail


Usefulness of fluorine-18-fluorodeoxyglucose positron emission tomography in a patient with Takayasu's arteritis associated with antiphospholipid syndrome.
MedLine Citation:
PMID:  16607057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 36-year-old woman was admitted for recurring chest pain and hemoptysis. Blood pressure in the right and left arms was equal, and no murmurs or bruits were heard. Body temperature was normal on admission and remained within the normal range during the hospital stay. C-reactive protein was slightly elevated (2.3 mg/dL) and lupus anticoagulant was positive. Angiography showed no abnormality of the aorta or its branches, but the left pulmonary artery showed occlusion at the proximal portion. Computed tomography (CT) revealed segmental wall thickening of the thoracic aorta. Fluorine-18-fluorodeoxyglucose positron emission tomography (18FDG PET) showed high uptake in the proximal portion of the left pulmonary artery and in the thoracic aorta with wall thickening on CT. Based on these findings, a diagnosis of Takayasu's arteritis associated with antiphospholipid syndrome was made and high-dose steroid therapy (prednisolone 30 mg/day) was started. Two months later, the C-reactive protein level had decreased from 2.3 mg/dL to 1.1 mg/dL, and both the focal wall thickening and (18)FDG uptake of the thoracic aorta were decreased. 18FDG PET was useful for evaluating the efficacy of the steroid therapy in addition to making a diagnosis of Takayasu's arteritis associated with antiphospholipid syndrome.
Authors:
Bunji Kaku; Takahiro Higuchi; Hounin Kanaya; Yuki Horita; Tsukasa Yamazaki; Yoshihide Uno; Hideki Itoh; Masanobu Namura; Masami Shimizu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  47     ISSN:  1349-2365     ISO Abbreviation:  -     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-11     Completed Date:  2006-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents / administration & dosage
Antiphospholipid Syndrome / complications*
Female
Fluorodeoxyglucose F18 / diagnostic use*
Humans
Positron-Emission Tomography*
Prednisolone / administration & dosage
Radiopharmaceuticals / diagnostic use*
Takayasu Arteritis / drug therapy,  radiography,  radionuclide imaging*
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Radiopharmaceuticals; 50-24-8/Prednisolone; 63503-12-8/Fluorodeoxyglucose F18

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