Document Detail

Usefulness of elevations in serum choline and free F2)-isoprostane to predict 30-day cardiovascular outcomes in patients with acute coronary syndrome.
MedLine Citation:
PMID:  19699337     Owner:  NLM     Status:  MEDLINE    
Our objectives were to evaluate the prognostic value of several biomarkers in patients with acute coronary syndrome (ACS) through an evaluation of the 30-day clinical outcomes. Multiple biomarkers have emerged as potentially useful in risk stratification of ACS. Specifically, markers of vascular inflammation and oxidative stress might be helpful in the determination of clinical outcomes. We evaluated patients presenting with chest pain. ACS was defined by symptoms of cardiac ischemia plus electrocardiographic changes or positive troponin I. Levels of serum troponin I, high sensitivity C-reactive protein, serum choline, and free F(2)-isoprostane were obtained. Patients were followed up for 30 days (n = 108) with determination of nonfatal myocardial infarction, congestive heart failure, need for revascularization, and death. Of the 108 patients, 26 had a cardiac event. Free F(2)-isoprostane and choline levels (but not high-sensitivity C-reactive protein levels) predicted 30-day cardiac events. To determine the value of choline and F(2)-isoprostane levels in predicting 30-day cardiac events, receiver operating curves were generated. The optimal cutoff point of these markers was a serum F(2)-isoprostane level of 124.5 pg/ml (r = 0.82) and a serum choline level of 30.5 mumol/L (r = 0.76). F(2)-isoprostane and choline had a positive predictive value of 57% and 44% and a negative predictive value of 90% and 89%, respectively. In conclusion, serum choline and free F(2)-isoprostane are predictors of cardiac events in ACS. A model that includes an array of biomarkers, including troponin, choline, and free F(2)-isoprostane, might be useful in predicting patients at greater risk of future events in ACS.
Rebecca M LeLeiko; Christopher S Vaccari; Srikanth Sola; Nadya Merchant; Sameer H Nagamia; Martin Thoenes; Bobby V Khan
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Publication Detail:
Type:  Journal Article     Date:  2009-06-24
Journal Detail:
Title:  The American journal of cardiology     Volume:  104     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  638-43     Citation Subset:  AIM; IM    
Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA.
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MeSH Terms
Acute Coronary Syndrome / blood*,  complications
Aged, 80 and over
Biological Markers / blood*
C-Reactive Protein / analysis
Cardiovascular Diseases / blood,  etiology
Choline / blood*
F2-Isoprostanes / blood*
Middle Aged
Predictive Value of Tests
ROC Curve
Risk Assessment
Reg. No./Substance:
0/Biological Markers; 0/F2-Isoprostanes; 62-49-7/Choline; 9007-41-4/C-Reactive Protein

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