Document Detail


Usefulness of electron beam tomography in adolescents and young adults with heterozygous familial hypercholesterolemia.
MedLine Citation:
PMID:  9843466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Because of the success of secondary prevention of coronary events by intense risk factor modification, a more precise measure of atherosclerosis in youth would have great clinical value both in the design of clinical trials for the demonstration of the usefulness of coronary disease prevention early in life and in guiding therapy. Identification of calcium in coronary arteries by electron beam tomography has been associated with severity of atherosclerosis in adults. METHODS AND RESULTS: Twenty-nine youths 11 to 23 years old with familial hypercholesterolemia (average LDL cholesterol, 5.95 mmol/L) underwent electron beam tomography as well as comprehensive risk factor assessment with measurement of total cholesterol, triglycerides, HDL cholesterol, lipoprotein (a), apolipoprotein E phenotype, blood pressure, body mass index, and history of tobacco use. Significant coronary calcium was identified in 7 of 29 subjects. Increased body mass index was significantly associated with the presence of coronary calcium (25.3 versus 20.6 kg/m2, P<0.03). No other risk factors were associated with the presence of coronary calcium. CONCLUSIONS: Coronary calcium, uncommonly identified before the fourth decade, was found in a significant percentage of adolescents and young adults with familial hypercholesterolemia. Overweight may increase the likelihood of coronary calcium being present in individuals already at high risk.
Authors:
S S Gidding; L C Bookstein; E V Chomka
Related Documents :
9551596 - Lipid-lowering therapy after coronary revascularization: the interventional cardiologis...
8874986 - Monotherapy with hmg-coa reductase inhibitors and secondary prevention in coronary arte...
17095906 - The safety and efficacy of achieving very low ldl-cholesterol concentrations with high ...
1858546 - The help-system in the treatment of severe hypercholesterolaemia: acute and long-term e...
19280086 - Minor troponin t elevation in patients 6 months after acute myocardial infarction: an o...
17896956 - Melatonin in cardiac ischemia/reperfusion-induced mitochondrial adaptive changes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  98     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-01-04     Completed Date:  1999-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2580-3     Citation Subset:  AIM; IM    
Affiliation:
Departments of Pediatrics and Preventive Medicine, Northwestern University Medical School, Children's Memorial Hospital, Chicago, IL 60614, USA. s-gidding@nwu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Coronary Disease / radiography*
Female
Heterozygote
Humans
Hyperlipoproteinemia Type II / complications,  radiography*
Male
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Spontaneous conversion and maintenance of sinus rhythm by amiodarone in patients with heart failure ...
Next Document:  Laminar shear stress-induced GRO mRNA and protein expression in endothelial cells.