| Usefulness of diffusion-weighted imaging in the localization of prostate cancer. | |
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MedLine Citation:
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PMID: 19019564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Advances in high-precision radiation therapy techniques for patients with prostate cancer permit selective escalation of the radiation dose delivered to the dominant intraprostatic lesion and improve the therapeutic ratio. We evaluated the value of diffusion-weighted imaging (DWI) for dominant intraprostatic lesion assessment. METHODS AND MATERIALS: The study population consisted of 23 patients with early prostate cancer. Before undergoing total prostatectomy, they were evaluated by means of magnetic resonance imaging, including DWI. T2-weighted imaging (T2WI) with and without DWI were retrospectively assessed by six independent observers. Imaging findings were compared with pathologic results from whole prostate specimens on a lesion-by-lesion basis. RESULTS: Pathologic study identified 43 lesions in 23 patients. On magnetic resonance imaging, the six observers correctly identified 11-22 of 43 lesions (sensitivity, 26-51%) on T2WI alone and 20-31 (sensitivity, 47-72%) on T2WI plus DWI. Positive predictive values were 42-73% on T2WI alone and 58-80% on T2WI plus DWI. For all observers, detection was higher on combined T2WI and DWI than on T2WI alone. CONCLUSION: Because the addition of DWI to T2WI improves the detectability of prostate cancer, DWI may offer a promising new approach for radiation therapy planning. |
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Authors:
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Hiroo Kajihara; Yoshiko Hayashida; Ryuji Murakami; Kazuhiro Katahira; Ryuichi Nishimura; Yasuyuki Hamada; Kousuke Kitani; Mitsuhiko Kitaoka; Yasuko Suzuki; Mika Kitajima; Toshinori Hirai; Shoji Morishita; Kazuo Awai; Yasuyuki Yamashita |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2008-11-18 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 74 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-11 Completed Date: 2009-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 399-403 Citation Subset: IM |
Affiliation:
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Department of Radiology, Kumamoto Chuo Hospital, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Diffusion Magnetic Resonance Imaging / methods* False Positive Reactions Humans Male Middle Aged Observer Variation Prostatectomy Prostatic Neoplasms / diagnosis*, pathology, surgery Retrospective Studies Sensitivity and Specificity |
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