Document Detail


Usefulness of detectable levels of troponin, below the 99th percentile of the normal range, as a clue to the presence of underlying coronary artery disease.
MedLine Citation:
PMID:  17719317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to evaluate whether markers of myocardial injury and ischemia are helpful in detecting coronary artery disease (CAD) in patients with stable angina. Venous blood was obtained before and after a bicycle exercise test in 47 outpatients with suspected CAD for measurement of cardiac troponin I (cTnI), heart-type fatty acid binding protein, and glycogen phosphorylase BB. Patients with a coronary artery stenosis >/=70% in diameter (n = 33) were compared with patients with coronary narrowing <50% (controls, n = 14). None of the markers increased after bicycle exercise testing. cTnI measured before and after exercise was higher in the CAD group than in controls (p <0.001). The area under the curve for diagnosis was greater when the cTnI value was detectable than with stress testing alone. In conclusion, baseline cTnI was of value in detecting CAD and also during follow-up in predicting the need for further revascularization.
Authors:
Olaf Schulz; Claudia Paul-Walter; Matthias Lehmann; Klaus Abraham; Gunnar Berghöfer; Ingolf Schimke; Allan S Jaffe
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-06-14
Journal Detail:
Title:  The American journal of cardiology     Volume:  100     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-10-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-9     Citation Subset:  AIM; IM    
Affiliation:
Interventionelle Kardiologie Spandau, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / blood
Area Under Curve
Biological Markers / blood
Coronary Disease / diagnosis*
Coronary Stenosis / blood
Exercise Test
Fatty Acid-Binding Proteins / blood
Female
Follow-Up Studies
Forecasting
Glycogen Phosphorylase, Muscle Form / blood
Humans
Male
Middle Aged
Myocardial Ischemia / blood
Predictive Value of Tests
Risk Factors
Troponin I / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Troponin I; EC 2.4.1.-/Glycogen Phosphorylase, Muscle Form

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