| Usefulness of detectable levels of troponin, below the 99th percentile of the normal range, as a clue to the presence of underlying coronary artery disease. | |
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MedLine Citation:
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PMID: 17719317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to evaluate whether markers of myocardial injury and ischemia are helpful in detecting coronary artery disease (CAD) in patients with stable angina. Venous blood was obtained before and after a bicycle exercise test in 47 outpatients with suspected CAD for measurement of cardiac troponin I (cTnI), heart-type fatty acid binding protein, and glycogen phosphorylase BB. Patients with a coronary artery stenosis >/=70% in diameter (n = 33) were compared with patients with coronary narrowing <50% (controls, n = 14). None of the markers increased after bicycle exercise testing. cTnI measured before and after exercise was higher in the CAD group than in controls (p <0.001). The area under the curve for diagnosis was greater when the cTnI value was detectable than with stress testing alone. In conclusion, baseline cTnI was of value in detecting CAD and also during follow-up in predicting the need for further revascularization. |
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Authors:
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Olaf Schulz; Claudia Paul-Walter; Matthias Lehmann; Klaus Abraham; Gunnar Berghöfer; Ingolf Schimke; Allan S Jaffe |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2007-06-14 |
Journal Detail:
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Title: The American journal of cardiology Volume: 100 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-27 Completed Date: 2007-10-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 764-9 Citation Subset: AIM; IM |
Affiliation:
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Interventionelle Kardiologie Spandau, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / blood Area Under Curve Biological Markers / blood Coronary Disease / diagnosis* Coronary Stenosis / blood Exercise Test Fatty Acid-Binding Proteins / blood Female Follow-Up Studies Forecasting Glycogen Phosphorylase, Muscle Form / blood Humans Male Middle Aged Myocardial Ischemia / blood Predictive Value of Tests Risk Factors Troponin I / blood* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/FABP3 protein, human; 0/Fatty Acid-Binding Proteins; 0/Troponin I; EC 2.4.1.-/Glycogen Phosphorylase, Muscle Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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