Document Detail

Usefulness of combined white blood cell count and plasma glucose for predicting in-hospital outcomes after acute myocardial infarction.
MedLine Citation:
PMID:  16728213     Owner:  NLM     Status:  MEDLINE    
Admission white blood cell (WBC) count and plasma glucose (PG) have been associated with adverse outcomes after acute myocardial infarction (AMI). This study investigated the joint effect of WBC count and PG on predicting in-hospital outcomes in patients with AMI. WBC count and PG were measured at the time of hospital admission in 3,665 patients with AMI. Patients were stratified into tertiles (low, medium, and high) based on WBC count and PG. Patients with a high WBC count had a 2.0-fold increase in in-hospital mortality compared with those with a low WBC count. Patients with a high PG level had a 2.7-fold increase in mortality compared with those with a low PG level. When a combination of different strata for each variable was analyzed, a stepwise increase in mortality was seen. There was a considerable number of patients with a high WBC count and low PG level or with a low WBC count and high PG level. These patients had an intermediate risk, whereas those with a high WBC count and high PG level had the highest risk, i.e., 4.8-fold increase in mortality, compared with those with a low WBC count and low PG level. Multivariate analysis was performed to assess the predictor for in-hospital mortality using WBC count and PG level as continuous variables and showed that WBC count and PG level were independently associated with in-hospital mortality. These findings suggested that a simple combination of WBC count and PG level might provide further information for predicting outcomes in patients with AMI.
Masaharu Ishihara; Sunao Kojima; Tomohiro Sakamoto; Yujiro Asada; Kazuo Kimura; Shunichi Miyazaki; Masakazu Yamagishi; Chuwa Tei; Hisatoyo Hiraoka; Masahiro Sonoda; Kazufumi Tsuchihashi; Nobuo Shinoyama; Takashi Honda; Yasuhiro Ogata; Hisao Ogawa;
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2006-04-06
Journal Detail:
Title:  The American journal of cardiology     Volume:  97     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-26     Completed Date:  2006-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1558-63     Citation Subset:  AIM; IM    
Department of Cardiology, Hiroshima City Hospital, Hiroshoma, Japan.
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MeSH Terms
Biological Markers / blood
Blood Cell Count
Blood Glucose / metabolism*
Hospital Mortality
Japan / epidemiology
Middle Aged
Myocardial Infarction / blood*,  mortality
Predictive Value of Tests
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose

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