Document Detail

Usefulness of carotid intima-media thickness measurement and peripheral B-mode ultrasound scan in the clinical screening of patients with coronary artery disease.
MedLine Citation:
PMID:  10778996     Owner:  NLM     Status:  MEDLINE    
Previous observational studies have shown a relationship between carotid intima-media thickness (IMT) and coronary artery disease (CAD). In this study the authors evaluated the accuracy of the common carotid IMT measurement in predicting the presence and severity of CAD and the additional information offered by the detection of carotid, iliac, and lower limb plaques. One hundred and fifty consecutive patients were subjected to coronary angiography and carotid, iliac, and lower limb ultrasound scan. The mean value of six IMT measurements of the far wall of the common carotid artery was calculated in each patient. The mean IMT was significantly correlated to the number of stenosed coronary vessels (r = 0.43, p<0.001), although the positive and negative predictive value of mean IMT in identifying patients with CAD was low (81% and 46%, respectively). The combined information offered by IMT measurements and peripheral (carotid, iliac, and lower limb) plaque detection was then used to obtain the best multivariate regression model able to predict CAD status. The multivariate model showed a highly significant multiple correlation coefficient (r = 0.60, p<0.0001) and a sharp improvement in the negative predictive value (92%) with respect to the univariable model. B-mode ultrasound scan including common carotid IMT measurement and peripheral plaque detection may be of clinical value in the screening of patients with CAD.
A Balbarini; F Buttitta; U Limbruno; A S Petronio; R Baglini; G Strata; R Mariotti; M Ciccone; M Mariani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  51     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-04     Completed Date:  2000-05-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-79     Citation Subset:  IM    
Cardiac and Thoracic Department, University of Pisa, Italy.
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MeSH Terms
Carotid Arteries / pathology*
Coronary Disease / diagnosis*,  pathology,  ultrasonography
Echocardiography, Doppler
Middle Aged
Predictive Value of Tests
Regression Analysis
Tunica Intima / pathology*

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