| Usefulness of atorvastatin in patients with heart failure due to inflammatory dilated cardiomyopathy and elevated cholesterol levels. | |
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MedLine Citation:
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PMID: 16516598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the safety, tolerability, and efficacy of statin therapy in patients with heart failure secondary to inflammatory dilated cardiomyopathy and moderately elevated low-density lipoprotein cholesterol levels. Seventy-four patients were randomized to receive atorvastatin 40 mg/day or conventional treatment for heart failure. After 6 months of therapy, the predefined primary efficacy end point (an increase of >5% in the absolute left ventricular ejection fraction and > or =2 selected criteria by echocardiography and a decrease in New York Heart Association functional class) was significant in the statin-treated patients (p = 0.004). Among secondary efficacy parameters, the quality-of-life index showed a trend suggesting the benefit of statin therapy (p = 0.055). In conclusion, the results of this study demonstrate that treatment with atorvastatin in addition to standard therapy for heart failure may significantly improve clinical outcomes in this cohort of patients. |
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Authors:
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Romuald Wojnicz; Krzysztof Wilczek; Ewa Nowalany-Kozielska; Bozena Szyguła-Jurkiewicz; Jolanta Nowak; Lech Poloński; Krzysztof Dyrbuś; Arkadiusz Badziński; Gabriela Mercik; Marian Zembala; Jan Wodniecki; Marius M Rozek |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-02-03 |
Journal Detail:
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Title: The American journal of cardiology Volume: 97 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-04-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 899-904 Citation Subset: AIM; IM |
Affiliation:
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3rd Department of Cardiology, Silesian Center for Heart Disease, Zabrze, Poland. wojnicz@dom.zab |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiomyopathy, Dilated / complications*, drug therapy Cholesterol, LDL / blood*, drug effects Drug Therapy, Combination Endpoint Determination Evaluation Studies as Topic Female Heart Failure / drug therapy, etiology* Heptanoic Acids / therapeutic use* Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / complications, drug therapy* Immunohistochemistry Male Myocardium / pathology Pyrroles / therapeutic use* Quality of Life Treatment Outcome Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin |
| Comments/Corrections | |
Comment In:
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Am J Cardiol. 2006 Sep 1;98(5):707
[PMID:
16923467
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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