| Usefulness of serial assessment of B-type natriuretic peptide, troponin I, and C-reactive protein to predict left ventricular remodeling after acute myocardial infarction (from the REVE-2 study). | |
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MedLine Citation:
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PMID: 21059429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular (LV) remodeling after myocardial infarction (MI) indicates a high risk of heart failure and death. However, LV remodeling is difficult to predict, and limited information is available on the association of cardiac biomarkers with LV remodeling. Our aim was to study the association of B-type natriuretic peptide (BNP), cardiac troponin I (cTnI), and C-reactive protein with LV remodeling after MI. We designed a prospective multicenter study including 246 patients with a first anterior Q-wave MI. Serial echocardiographic studies were performed at hospital discharge and 3 months and 1 year after MI; quantitative analysis was performed at a core echocardiographic laboratory. Blood samples for determination of BNP, cTnI, and C-reactive protein levels were obtained at hospital discharge and the 1-month, 3-month, and 1-year follow up visits. One-year echocardiographic follow-up was obtained in 226 patients. End-diastolic volume increased from 52.3 ± 13.8 ml/m(2) at baseline to 62.3 ± 18.4 ml/m(2) at 1 year (p <0.0001); LV remodeling (>20% increase in end-diastolic volume) was observed in 87 patients (38%). At baseline, we found significant univariate relations between LV remodeling and the 3 biomarkers. During follow-up, high BNP levels and persistently detectable levels of cTnI were associated with LV remodeling. In multivariate analysis, none of the 3 biomarkers at baseline was independently predictive of LV remodeling. In contrast, during follow-up, high BNP and positive cTnI were independently associated with LV remodeling. In conclusion, circulating cardiac biomarkers may reflect pathophysiologic processes implicated in LV remodeling after MI. Determination of BNP and cTnI during follow-up can help refine risk stratification. |
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Authors:
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Marie Fertin; Bernadette Hennache; Martial Hamon; Pierre V Ennezat; Frédéric Biausque; Mariam Elkohen; Olivier Nugue; Olivier Tricot; Nicolas Lamblin; Florence Pinet; Christophe Bauters |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2010-10-01 |
Journal Detail:
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Title: The American journal of cardiology Volume: 106 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-09 Completed Date: 2010-12-02 Revised Date: 2011-03-16 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1410-6 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Centre Hospitalier Régional et Universitaire de Lille, Lille, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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C-Reactive Protein
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analysis* Female Humans Male Middle Aged Myocardial Infarction / blood* Natriuretic Peptide, Brain / blood* Predictive Value of Tests Prospective Studies Troponin I / blood* Ventricular Remodeling* |
| Chemical | |
Reg. No./Substance:
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0/Troponin I; 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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Am J Cardiol. 2011 Mar 1;107(5):797-8
[PMID:
21316510
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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