| Usefulness of the right ventricular systolic to diastolic duration ratio to predict functional capacity and survival in children with pulmonary arterial hypertension. | |
| | |
MedLine Citation:
|
PMID: 20643259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The objective of this study was to investigate the systolic to diastolic duration ratio (S:D ratio) in children with pulmonary arterial hypertension (PAH) and its association with right ventricular (RV) performance, hemodynamics, 6-minute walk test, clinical outcomes, and survival. We reviewed 503 serial echocardiograms in 47 children with PAH (mean pulmonary artery pressure >or=25 mm Hg) and compared the S:D ratio, assessed from Doppler flow of tricuspid valve regurgitation, to that in 47 age-matched controls. We reviewed echocardiograms, catheterization data, 6-minute walk tests, clinical data, lung transplantation, and death and used univariate linear regression models with a maximum likelihood algorithm for parameter estimation to investigate associations between S:D ratio and RV function, hemodynamics, functional capacity, and clinical outcomes. The S:D ratio was significantly higher in patients than in controls (1.38 +/- 0.61 vs 0.72 +/- 0.16, p <0.001). A higher S:D ratio was associated with worse echocardiographic RV fractional area of change, worse catheterization hemodynamics, shorter 6-minute walk distance, and worse clinical outcomes independent of pulmonary resistance or pressures. An increase of 0.1 in the S:D ratio was associated with a 13% increase in yearly risk for lung transplantation or death (hazard ratio 1.13, p <0.001). An S:D ratio 1.00 to 1.40 was associated with a moderate risk and an S:D ratio >1.40 was associated with a high risk of a negative outcome. In conclusion, in children with PAH, an increased S:D ratio is temporally associated with worse RV function, hemodynamics, exercise capability, clinical status, and survival. |
| | |
Authors:
|
Jaime Alkon; Tilman Humpl; Cedric Manlhiot; Brian W McCrindle; Janette T Reyes; Mark K Friedberg |
Related Documents
:
|
16353449 - Functional and metabolic recovery of the right ventricle during bosentan therapy in idi... 15907409 - Continuous haemodynamic monitoring during exercise in patients with pulmonary hypertens... 9429049 - Relationship of fat embolism to haemodynamic and echocardiographic changes during cemen... 16006539 - Myocardial perfusion reserve in adults with cyanotic congenital heart disease. 9752899 - Renal artery clipping attenuates the progression of adriamycin nephropathy. 7923689 - The renin-angiotensin system and volume overload-induced changes in cardiac collagen an... 3605339 - Three-dimensional imaging of the stomach: role of pylorus in the emptying of liquids. 22383899 - Clinical and pre-clinical applications of the transcendental meditation program in the ... 1649859 - Psychological, biological and health behavior predictors of blood pressure changes in m... |
Publication Detail:
|
Type: Journal Article Date: 2010-06-18 |
Journal Detail:
|
Title: The American journal of cardiology Volume: 106 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-20 Completed Date: 2010-08-12 Revised Date: 2010-11-23 |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 430-6 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Pediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Case-Control Studies Child Child, Preschool Diastole Echocardiography, Doppler Exercise Test Female Hemodynamics Humans Hypertension, Pulmonary / physiopathology*, ultrasonography Infant Infant, Newborn Linear Models Male Predictive Value of Tests Respiratory Function Tests Survival Analysis Systole Ventricular Dysfunction, Right / physiopathology, ultrasonography Young Adult |
| Comments/Corrections | |
Comment In:
|
Am J Cardiol. 2010 Nov 15;106(10):1524
[PMID:
21059452
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Left Ventricular Diastolic Heart Failure in Teenagers Who Underwent Balloon Aortic Valvuloplasty in ...
Next Document: Electrocardiographic Changes Resulting From Pericardial Effusion Drainage.