Document Detail

Usefulness of plasma galectin-3 levels in systolic heart failure to predict renal insufficiency and survival.
MedLine Citation:
PMID:  21600537     Owner:  NLM     Status:  MEDLINE    
Galectin-3 plays an important role in fibroblast activation and fibrosis in animal models. Increased galectin-3 levels are associated with poor long-term survival in heart failure (HF). We examined the relation between plasma galectin-3 levels and myocardial indexes of systolic HF. We measured plasma galectin-3 in 133 subjects with chronic HF and 45 with advanced decompensated HF using echocardiographic and hemodynamic evaluations. In the chronic HF cohort, median plasma galectin-3 level was 13.9 ng/ml (interquartile range 12.1 to 16.9). Higher galectin-3 was associated with more advanced age (r = 0.22, p = 0.010), poor renal function (estimated glomerular filtration rate, r = -0.24, p = 0.007; cystatin C, r = 0.38, p <0.0001) and predicted all-cause mortality (hazard ratio 1.86, 95% confidence interval 1.36 to 2.54, p <0.001). In multivariate analysis, galectin-3 remained an independent predictor of all-cause mortality after adjusting for age, estimated glomerular filtration rate, left ventricular (LV) ejection fraction, and mitral early diastolic myocardial relaxation velocity at septal mitral annulus (hazard ratio 1.94, 95% confidence interval 1.30 to 2.91, p = 0.001). However, galectin-3 did not predict the combined end point of all-cause mortality, cardiac transplantation, or HF hospitalization (p >0.05). Furthermore, there were no relations between galectin-3 and LV end-diastolic volume index (r = -0.05, p = 0.61), LV ejection fraction (r = 0.10, p = 0.25), or LV diastolic function (mitral early diastolic myocardial relaxation velocity at septal mitral annulus, r = 0.06, p = 0.52; left atrial volume index, r = 0.08, p = 0.41). In the advanced decompensated HF cohort, we did not observe any relation between galectin-3 and echocardiographic or hemodynamic indexes. In conclusion, high plasma galectin-3 levels were associated with renal insufficiency and poorer survival in patients with chronic systolic HF. However, we did not observe a relation between galectin-3 and echocardiographic or hemodynamic indexes.
W H Wilson Tang; Kevin Shrestha; Zhili Shao; Allen G Borowski; Richard W Troughton; James D Thomas; Allan L Klein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-19
Journal Detail:
Title:  The American journal of cardiology     Volume:  108     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-15     Completed Date:  2011-09-13     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  385-90     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Ohio, USA.
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MeSH Terms
Age Factors
Chronic Disease
Cohort Studies
Echocardiography, Doppler
Follow-Up Studies
Galectin 3 / blood*
Glomerular Filtration Rate / physiology
Heart Failure, Systolic / blood*,  mortality,  ultrasonography
Hemodynamics / physiology
Kaplan-Meier Estimate
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Reference Values
Renal Insufficiency / blood*,  mortality,  ultrasonography
Survival Rate
Ventricular Dysfunction, Left / blood,  mortality,  ultrasonography
Grant Support
Reg. No./Substance:
0/Galectin 3

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