Document Detail


Usefulness of Hemoglobin Level to Predict Long-Term Mortality in Patients With Asymptomatic Carotid Narrowing by Ultrasonography.
MedLine Citation:
PMID:  22921994     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Anemia is associated with the cardiovascular outcome in healthy subjects but its impact on outcome in patients with cardiovascular disease has not yet been fully understood. Therefore, we assessed the long-term influence of hemoglobin on all-cause and cardiovascular mortality in patients with atherosclerotic disease. We prospectively studied 1,065 of 1,286 consecutive patients with asymptomatic carotid narrowing. During a median follow-up of 6.2 years, corresponding to 5,551 overall person-years, 275 patients (25.8%) died. Continuous measures of hemoglobin displayed a significant inverse effect on all-cause mortality and cardiovascular mortality (adjusted hazard ratio [HR] for increase of 1 SD of hemoglobin 0.73, 95% confidence interval [CI] 0.64 to 0.83; p <0.001) and adjusted HR 0.76, 95% CI 0.64 to 0.89; p = 0.001, respectively). The cumulative 6-year survival rate was 61%, 79%, 80%, and 81% in the first, second, third, and fourth quartile of hemoglobin (log-rank p <0.001). Patients within the first quartile (<12.9 g/dl) had a significantly increased risk of all-cause mortality (adjusted HR 1.93, 95% CI 1.46 to 2.54, p <0.001) and cardiovascular mortality (adjusted HR 1.68, 95% CI 1.19 to 2.36, p = 0.003) compared to patients with greater levels. In conclusion, our study has demonstrated a significant association with hemoglobin levels and all-cause and cardiovascular mortality in patients with carotid narrowing. Nevertheless, additional research, in terms of randomized controlled trials, is needed to warrant these findings and to evaluate potential therapeutic interventions.
Authors:
Georg Goliasch; Martin Schillinger; Florian J Mayer; Anna Wonnerth; Renate Koppensteiner; Erich Minar; Gerald Maurer; Alexander Niessner; Matthias Hoke
Related Documents :
22766134 - Determinants and effects of vitamin d supplementation on serum 25-hydroxy-vitamin d lev...
8113584 - Gastric syphilis. report of seven cases and review of the literature.
2147664 - Gastric emptying and subjective symptoms of nausea: lack of effects of a 5-hydroxytrypt...
3204684 - Serum testosterone level in the peripheral vein and the perigastric draining vein of pa...
24294924 - Airway oxidative stress in chronic cough.
25158694 - Small airway dysfunction is associated to excessive bronchoconstriction in asthmatic pa...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  The American journal of cardiology     Volume:  -     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cardiology, Medical University Vienna, Vienna, Austria; Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of short-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on microRNA expression in zebr...
Next Document:  Determining the Risks of Magnetic Resonance Imaging at 1.5 Tesla for Patients With Pacemakers and Im...