Document Detail

Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma.
MedLine Citation:
PMID:  15362373     Owner:  NLM     Status:  MEDLINE    
We studied the diagnostic value of Cdx2 to distinguish mucinous bronchioloalveolar carcinoma from mucinous colorectal adenocarcinoma metastatic to the lung. We retrieved 92 via the hospital computer system, including 30 mucinous bronchioloalveolar carcinomas, 32 nonmucinous bronchioloalveolar carcinomas, and 30 mucinous colorectal adenocarcinomas metastatic to the lung. All cases were confirmed by clinical history and surgical resection with occasional immunohistochemical studies. Cases were stained with antibodies against Cdx2, thyroid transcription factor-1 (TTF-1), cytokeratin (CK) 7, and CK20. Bronchioloalveolar carcinoma, mucinous type, showed positive staining for Cdx2, TTF-1, CK7, and CK20 in 0 (0%), 5 (17%), 30 (100%), and 18 (60%) of 30 cases, respectively; nonmucinous tumors were positive in 0 (0%), 30 (94%), 32 (100%), and 0 (0%) of 32 cases, respectively. For colorectal adenocarcinoma, the positive staining for Cdx-2, TTF-1, CK7, and CK20 was 29 (97%), 0 (0%), 7 (23%), and 29 (97%) of 30 cases, respectively. Our results demonstrated Cdx2 as a sensitive and specific marker for differentiating metastatic colorectal adenocarcinoma from mucinous bronchioloalveolar adenocarcinoma.
Reda S Saad; Patrick Cho; Jan F Silverman; Yulin Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  122     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2004-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  421-7     Citation Subset:  AIM; IM    
Department of Pathology, Allegheny General Hospital, Pittsburgh, PA, USA.
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MeSH Terms
Adenocarcinoma / secondary*
Adenocarcinoma, Bronchiolo-Alveolar / pathology*
Avian Proteins*
Colorectal Neoplasms / pathology*
Diagnosis, Differential
Homeodomain Proteins / biosynthesis*
Intermediate Filament Proteins / biosynthesis
Keratins / biosynthesis
Lung Neoplasms / pathology*,  secondary
Nuclear Proteins / biosynthesis
Transcription Factors / biosynthesis
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Avian Proteins; 0/Homeodomain Proteins; 0/Intermediate Filament Proteins; 0/KRT20 protein, human; 0/KRT7 protein, human; 0/Keratin-20; 0/Keratin-7; 0/Nuclear Proteins; 0/Transcription Factors; 0/Tumor Markers, Biological; 0/thyroid nuclear factor 1; 68238-35-7/Keratins

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