Document Detail

Usefulness of B-type natriuretic peptide (BNP) as a screen for left ventricular abnormalities in diabetes mellitus.
MedLine Citation:
PMID:  15525883     Owner:  NLM     Status:  MEDLINE    
Cardiovascular disease is the leading cause of morbidity and mortality in diabetic subjects. Diabetes, independently of the mechanism, is associated with an increased risk of left ventricular hypertrophy, left ventricular dysfunction and coronary artery disease. B-type natriuretic peptide (BNP) is a cardiac neurohormone predominantly released from the cardiac ventricles in response to left ventricular volume expansion and pressure overload. Numerous studies have shown that BNP levels are elevated in asymptomatic or symptomatic left ventricular dysfunction, hypertrophy and coronary artery disease. BNP testing plays an important role in the screening and diagnosis of left ventricular dysfunction by improving the performance of non-specialist physicians in diagnosing heart failure. In clinical practice, BNP testing is best used as a 'rule out' test targeted to patients at high risk for left-ventricular dysfunction, such as those with diabetes. Studies are needed to establish if this promising biological tool, in the next future, would assist the management of diabetic patients.
S Cosson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetes & metabolism     Volume:  30     ISSN:  1262-3636     ISO Abbreviation:  Diabetes Metab.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-11-04     Completed Date:  2004-12-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  France    
Other Details:
Languages:  eng     Pagination:  381-6     Citation Subset:  IM    
Service de Cardiologie, Hôpital Lariboisière, Paris, France.
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MeSH Terms
Biological Markers / blood
Blood Pressure
Diabetic Angiopathies / blood,  diagnosis*
Diastole / physiology
Heart Ventricles
Natriuretic Peptide, Brain / blood*
Systole / physiology
Ventricular Dysfunction, Left / blood,  diagnosis*
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain

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