Document Detail

Usefulness of 6-minute walk test, plasma neurohumoral and cytokine activation in the assessment of symptomatic patients with left ventricle dysfunction caused by chronic severe mitral valve regurgitation.
MedLine Citation:
PMID:  20306889     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of our study was to select the most relevant markers of impaired left ventricle (LV) function in patients with heart failure (HF) symptoms due to severe chronic mitral regurgitation (MR). METHODS AND RESULTS: Thirty-six patients with decompensated HF due to severe MR underwent echocardiography, 6-minute walk test (6MWT) and measurements of plasma renin activity, angiotensin II, aldosterone, noradrenaline (NA), brain natriuretic peptide (BNP), tumour necrosis factor alpha (TNFalpha) with its receptors, and interleukine-6. Patients presented with significant neurohumoral/cytokine activation. By stepwise multiple regression analysis the strongest prediction model for 6MWT included LVEDVI (R2 = 0.95, P = 0.024), BNP (R2 = 0.67, P = 0.0006), IL-6 (R2 = 0.90, P = 0.044); for BNP: 6MWT (R2 = 0.36, P = 0.003), LA (R2 = 0.56, P = 0.0077), LVESVI (R2 = 0.83, P = 0.0072); for NA: EF (R2 = 0.4 1, P = 0.036), and for TNFalpha: LVESVI (R2 = 0.65, P = 0.003). CONCLUSIONS: 6MWT and neurohumoral markers (mainly BNP, but also NA and TNFalpha) are good predictors of the degree of LV remodelling, showing an independent correlation with the level of LV dilatation/dysfunction in chronic severe MR.These assessments may supplement standard echocardiography in LV decompensation due to severe MR.
Przemys?aw Leszek; Anna Klisiewicz; Jadwiga Janas; Andrzej Biederman; Walerian Piotrowski; Tomasz Rywik; Jerzy Korewicki
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta cardiologica     Volume:  65     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
Heart Failure and Transplantation Department, National Institute of Cardiology, Warszawa, Poland.
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MeSH Terms
Biological Markers / blood
Biotransformation / physiology*
Chronic Disease
Cytokines / blood*
Enzyme-Linked Immunosorbent Assay
Exercise Test / methods*
Follow-Up Studies
Middle Aged
Mitral Valve Insufficiency / complications*,  diagnosis,  physiopathology
Renin-Angiotensin System / physiology*
Severity of Illness Index
Ventricular Dysfunction, Left / blood,  diagnosis*,  etiology
Ventricular Remodeling / physiology
Reg. No./Substance:
0/Biological Markers; 0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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