Document Detail

Use of voriconazole in treatment of Scedosporium apiospermum infection: case report.
MedLine Citation:
PMID:  9574724     Owner:  NLM     Status:  MEDLINE    
We report a case of disseminated Scedosporium apiospermum infection in a neutropenic patient with acute myeloid leukemia. Due to progression of the mycosis after 7 days of amphotericin B lipid complex therapy and to high susceptibility of the mold to voriconazole in vitro, the patient was treated with intravenous voriconazole. After a few days of therapy, fever disappeared and skin lesions improved. However, the patient died after 1 month due to intestinal bleeding. Despite a negative outcome, this case seems to indicate a promising role for voriconazole in the treatment of S. apiospermum infections.
C Girmenia; G Luzi; M Monaco; P Martino
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  36     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-09     Completed Date:  1998-06-09     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1436-8     Citation Subset:  IM    
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy. GIRMENIA@BCE.MED.UNIROMA1.IT
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MeSH Terms
Acute Disease
Antifungal Agents / therapeutic use*
Dermatomycoses / drug therapy*,  etiology
Fatal Outcome
Leukemia, Myeloid / complications
Pyrimidines / therapeutic use*
Triazoles / therapeutic use*
Reg. No./Substance:
0/Antifungal Agents; 0/Pyrimidines; 0/Triazoles; 0/voriconazole

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