Document Detail

Use of ventriculography in assessing performance and oxygen consumption of the left ventricle: response to altered afterload.
MedLine Citation:
PMID:  7151154     Owner:  NLM     Status:  MEDLINE    
Using ventriculography, we assessed the relationship between performance, blood flow, and oxygen consumption of the left ventricle in seven anesthetized dogs. Ventricular loading was varied between increased and decreased afterload by intraaortic infusion of angiotensin and acetylcholine. Intact ventricular performance was measured by computer-based analysis of biplane left ventriculograms. Myocardial blood and flow distribution was determined by radioactive microspheres, and oxygen consumption was measured by coronary arteriovenous oxygen difference times blood flow. When left ventricular systolic pressure rose, tension-time index, stress-time index, stroke work, and minute work derived from the ventriculogram increased significantly; end diastolic volume increased; and ejection fraction decreased. Inverse responses occurred to a smaller degree when left ventricular pressure was reduced. With increased pressure, myocardial blood flow and oxygen consumption changed proportionately to minute work. Correlation coefficients between oxygen consumption and stroke work (0.782), oxygen consumption and minute work (0.769), oxygen consumption and tension-time index (0.792), and between oxygen consumption and stress-time index (0.740) all indicate that performance measures obtained from ventriculograms can be used to estimate changes in oxygen consumption during acute afterload changes. These measurements can be applied to data obtained from clinical catheterization studies in man and suggest that changes in myocardial performance and oxygen consumption can be estimated from ventriculographic data.
A A Bove; A W McGinnis; J L Michele
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Catheterization and cardiovascular diagnosis     Volume:  8     ISSN:  0098-6569     ISO Abbreviation:  Cathet Cardiovasc Diagn     Publication Date:  1982  
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7508512     Medline TA:  Cathet Cardiovasc Diagn     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-89     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / administration & dosage
Coronary Circulation / drug effects
Diastole / drug effects
Heart Rate / drug effects
Heart Ventricles / metabolism,  radiography*
Infusions, Intra-Arterial
Oxygen Consumption* / drug effects
Stroke Volume / drug effects
Systole / drug effects
Ventricular Function
Reg. No./Substance:
11128-99-7/Angiotensin II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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