Document Detail


Use of ursodeoxycholic acids in a dog with chronic hepatitis: effects on serum hepatic tests and endogenous bile acid composition.
MedLine Citation:
PMID:  9183773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A dog with severe cholestasis secondary to chronic hepatitis was treated with ursodeoxycholic acid (UDCA) PO. After 2 weeks of daily treatment, the dog was more active and had an improved appetite. Monthly serum biochemical determinations and analysis of individual bile acid profiles documented improvement in hepatobiliary tests and a marked reduction in the concentrations of potentially hepatotoxic endogenous bile acids. These effects were maintained for approximately 6 months. The findings in this dog are similar to those reported for human patients treated with UDCA and provide preliminary evidence in support of its continued evaluation in the treatment of cholestatic liver disease in the dog.
Authors:
D J Meyer; M B Thompson; D F Senior
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  11     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-08-19     Completed Date:  1997-08-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-7     Citation Subset:  IM    
Affiliation:
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / blood*
Cholestasis / drug therapy,  etiology,  veterinary*
Dog Diseases / blood,  drug therapy*
Dogs
Female
Hepatitis, Animal / blood,  complications*
Liver Function Tests
Ursodeoxycholic Acid / therapeutic use*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 128-13-2/Ursodeoxycholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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