Document Detail

Use of unnatural amino acids for design of novel organomodified clays as components of nanocomposite biomaterials.
MedLine Citation:
PMID:  20308111     Owner:  NLM     Status:  MEDLINE    
Sodium montmorillonite (Na-MMT) clay was modified with three different unnatural amino acids in order to design intercalated clay structures that may be used for bone biomaterials applications. Prior work on polymer-clay nanocomposites (PCNs) has indicated the effect of the appropriate choice of modifiers on enhancing properties of PCNs. Our X-ray diffraction results indicate an increase in the d-spacing of Na-MMT clay after it was modified with the three unnatural amino acids. Transmission Fourier transform infrared spectroscopy experiments were carried out on the unmodified and modified MMT clay samples to study the molecular interactions between the amino acids used as modifiers and the Na-MMT clay. Cell culture experiments showed that the Na-MMT clay modified with the three amino acids was biocompatible as were the modified clay-incorporated films of chitosan/polygalacturonic acid/hydroxyapatite.
Kalpana S Katti; Avinash H Ambre; Nicholas Peterka; Dinesh R Katti
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Philosophical transactions. Series A, Mathematical, physical, and engineering sciences     Volume:  368     ISSN:  1364-503X     ISO Abbreviation:  Philos Trans A Math Phys Eng Sci     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-05-20     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  101133385     Medline TA:  Philos Trans A Math Phys Eng Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1963-80     Citation Subset:  IM    
Department of Civil Engineering, North Dakota State University, Fargo, ND 58105, USA.
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MeSH Terms
Aluminum Silicates*
Amino Acids / chemistry*
Bentonite / chemistry
Biocompatible Materials / chemistry*
Cell Culture Techniques / methods
Chitosan / chemistry
Durapatite / chemistry
Materials Testing
Nanocomposites / chemistry
Nanostructures / chemistry*
Osteoblasts / metabolism
Pectins / chemistry
Polymers / chemistry
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
Reg. No./Substance:
0/Aluminum Silicates; 0/Amino Acids; 0/Biocompatible Materials; 0/Pectins; 0/Polymers; 1302-78-9/Bentonite; 1302-87-0/clay; 1306-06-5/Durapatite; 9012-76-4/Chitosan; 9046-38-2/polygalacturonic acid

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