| Use of topiramate for glossodynia. | |
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MedLine Citation:
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PMID: 17716328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Glossodynia is a multifunctional disorder characterized by painful sensations in the mouth and throat and especially on the tongue. It is commonly cured by long-term therapy with systemic regimens of anxiolytics, antidepressants, and anticonvulsants. CASE: We report here the case of a 65-year-old woman with a 4-month history of glossodynia. Clinical and laboratory evaluations performed the diagnosis of idiopathic glossodynia, and several treatments with carbamazepine and then with gabapentin induced the development of serious adverse reaction. Only treatment with topiramate has been able to induce a complete improvement of symptoms. DISCUSSION: The pathogenesis of idiopathic glossodynia remains unclear, since it recently has been suggested as a possible neuropathic basis of burning mouth syndrome, demonstrating an altered excitability in the trigeminal nociceptive pathway at peripheral and/or central nervous system level. The various mechanisms of topiramate, which act at different neural transmission levels, blocking sodium and calcium channels, enhancing GABA concentration, and decreasing glutamate function at postsynaptic site, may explain the effects of topiramate in our patient. CONCLUSION: Therefore, we suggest that topiramate could represent a useful therapeutic option in the treatment of glossodynia. |
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Authors:
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Antonio Siniscalchi; Luca Gallelli; Norma Maria Marigliano; Paola Orlando; Giovambattista De Sarro |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pain medicine (Malden, Mass.) Volume: 8 ISSN: 1526-2375 ISO Abbreviation: Pain Med Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-08-24 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100894201 Medline TA: Pain Med Country: United States |
Other Details:
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Languages: eng Pagination: 531-4 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Neurology Division, Annunziata Hospital, Cosenza, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anticonvulsants / therapeutic use* Female Fructose / analogs & derivatives*, therapeutic use Glossalgia / drug therapy* Humans Pain Measurement |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 30237-26-4/Fructose; 97240-79-4/topiramate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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