Document Detail

Use of technicon H*1 technology in routine thalassaemia screening.
MedLine Citation:
PMID:  1339929     Owner:  NLM     Status:  MEDLINE    
In a retrospective study of 36 cases of alpha-thalassaemia trait, 43 cases of beta-thalassaemia trait and 45 cases of iron deficiency, we have assessed the performance of the Technicon H*1 erythrogram, the hypochromia minus microcytosis (H-M) index, and the discriminant function (DF). The diagnostic accuracy of the erythrogram pattern was 83.3% for alpha-thalassaemia trait and 95.3% for beta-thalassaemia trait. The diagnostic accuracy for the H-M index was 19.4% for alpha-thalassaemia trait, 72.1% for beta-thalassaemia trait and 91.1% for iron deficiency. By comparison, the DF gave a diagnostic accuracy of 75.0% for alpha-thalassaemia trait, 81.4% for beta-thalassaemia trait and 88.9% for iron deficiency when using a locally derived value for the constant (k) = 19.2. Our study shows that the H*1 erythrogram pattern, the H-M index and the DF are useful predictive indicators in routine laboratory screening for thalassaemia.
E P Robertson; A Pollock; K S Yau; L C Chan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Medical laboratory sciences     Volume:  49     ISSN:  0308-3616     ISO Abbreviation:  Med Lab Sci     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-11-19     Completed Date:  1993-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7609161     Medline TA:  Med Lab Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Department of Pathology, University of Hong Kong, Queen Mary Hospital Compound.
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MeSH Terms
Discriminant Analysis
Erythrocyte Count / instrumentation*,  methods
Retrospective Studies
Sensitivity and Specificity
Thalassemia / diagnosis*

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