| Use of tacrolimus in steroid- and cyclophosphamide-resistant minimal change nephrotic syndrome. | |
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MedLine Citation:
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PMID: 14582073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors report a case of adult-onset minimal change nephrotic syndrome (MCNS) that was resistant to steroid and cyclophosphamide therapy. Introduction of cyclosporin induced an usual cutaneous reaction of severe flushing attacks. Tacrolimus successfully alleviated both the nephrotic syndrome and the cutaneous side effect associated with cyclosporin use. The antiproteinuric mechanisms of tacrolimus and its potential in treating refractory MCNS and other forms of primary glomerulonephritides are discussed. |
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Authors:
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Sydney Tang; Anthony W C Tang; Man Kei Tam; Yiu Wing Ho |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 42 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-28 Completed Date: 2004-04-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: E13-5 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Hong Kong. scwtang@hkucc.hku.hk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents
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therapeutic use Cyclophosphamide / therapeutic use Cyclosporine / adverse effects Drug Eruptions / etiology Drug Resistance Female Flushing / chemically induced Humans Immunosuppressive Agents / adverse effects, therapeutic use* Middle Aged Nephrosis, Lipoid / drug therapy* Prednisolone / therapeutic use Remission Induction Steroids / therapeutic use Tacrolimus / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Immunosuppressive Agents; 0/Steroids; 109581-93-3/Tacrolimus; 50-18-0/Cyclophosphamide; 50-24-8/Prednisolone; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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