Document Detail


Use of subcutaneous recombinant human erythropoietin in children undergoing continuous cycling peritoneal dialysis.
MedLine Citation:
PMID:  2926567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five anemic, transfusion-dependent patients aged 12 to 18 years, who had end-stage renal disease (mean hematocrit value 22 +/- 0.31%) and were on a regimen of peritoneal dialysis, were treated with recombinant human erythropoietin (rHuEpo), which was self-administered at home by subcutaneous injections thrice weekly at an initial dosage of 150 U/kg. All patients had an increase in the reticulocyte count and hemoglobin concentration, and none required further transfusions. The hematocrit level rose to a mean of 33.04 +/- 1.86% within 3 weeks of rHuEpo therapy, and the dosage was adjusted to keep the hematocrit level between 32% and 38% indefinitely. Currently four of these patients require only one dose a week to sustain the hematocrit level. No antibodies to the rHuEpo were formed. Three patients had an exacerbation of hypertension, which required an adjustment in antihypertensive therapy. No other side effects were noted. The results demonstrate that rHuEpo is effective in correcting the anemia of end-stage renal disease, thereby eliminating the associated clinical symptoms and the need for further blood transfusions.
Authors:
L Sinai-Trieman; I B Salusky; R N Fine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  114     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  550-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of California, Los Angeles Center for the Health Sciences.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anemia / drug therapy*,  etiology
Child
Erythropoietin / therapeutic use*
Female
Hematocrit
Humans
Kidney Failure, Chronic / complications*,  therapy
Male
Peritoneal Dialysis
Recombinant Proteins / therapeutic use
Grant Support
ID/Acronym/Agency:
M01-RR00865/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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