Document Detail


Use of statin drugs in women.
MedLine Citation:
PMID:  12183858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Risk factors associated with the progression of coronary disease are the same in women and men, although there are some quantitative differences. Diabetic women, for example, are exquisitely sensitive to the development of atherosclerosis. There is no clinical trial devoted to the study of cholesterol lowering in women. A meta-analysis of recent statin trials with clinical endpoints, however, demonstrates that cholesterol lowering is as beneficial in women as it is in men. Hormone replacement therapy has not been demonstrated in a clinical trial to be of benefit, even though there is considerable observational, epidemiology and basic science evidence that indicates that it might be. It is important that the risk of coronary disease and stroke, particularly in older women, be recognized. Patients at risk should receive cholesterol-lowering treatment with statin drugs to prevent both atherosclerotic morbidity and mortality.
Authors:
John C LaRosa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  20     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-08-19     Completed Date:  2003-01-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  S70-2     Citation Subset:  IM    
Affiliation:
State University of New York, Downstate Medical Center, Brooklyn, New York, USA. jclarosa@downstate.ed
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MeSH Terms
Descriptor/Qualifier:
Anticholesteremic Agents / therapeutic use*
Clinical Trials as Topic
Coronary Disease / drug therapy,  epidemiology
Estrogen Replacement Therapy
Estrogens / therapeutic use
Europe / epidemiology
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Male
Practice Guidelines as Topic
Risk Factors
United States / epidemiology
Women's Health
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Estrogens; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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