Document Detail


Use of standardized and conventional allergen extracts in prick skin testing.
MedLine Citation:
PMID:  1545087     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined whether commercially available conventional and standardized allergen extracts differ enough in potency to affect routine prick skin test results. Extracts of white oak, timothy, Bermuda, Russian thistle, short ragweed, sagebrush, Alternaria, and cat dander were examined in allergic patients and in nonatopic subjects with no personal or family history of asthma, rhinitis, or eczema. Conventional nonstandardized extracts (1:10 or 1:20 wt/vol) from two sources were compared with three concentrations (100,000, 10,000, and 1000 AU/ml) of a single standardized extract. Preparations were compared in the allergic patients with computerized planimetry, and in all patients and subjects with a conventional skin test grading system. Skin test area for the conventional extracts generally fell between the 10,000 and 100,000 AU/ml concentrations of the standardized extract. Skin test reactivity to at least one allergen extract occurred in 31% of the nonatopic subjects; there was no difference between the number of 3+ and 4+ reactions for conventional and standardized extracts. Results indicate that standardized and conventional extracts are frequently similar, but are not directly interchangeable.
Authors:
B J Lavins; W K Dolen; H S Nelson; R W Weber
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  89     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-04-13     Completed Date:  1992-04-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  658-66     Citation Subset:  AIM; IM    
Affiliation:
Allergy-Immunology Service, Fitzsimons Army Medical Center, Aurora, CO 80045-5001.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Allergens / diagnostic use*
Dose-Response Relationship, Immunologic
Evaluation Studies as Topic
Humans
Hypersensitivity, Immediate / diagnosis
Middle Aged
Skin Tests / methods*,  standards
Chemical
Reg. No./Substance:
0/Allergens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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