Document Detail


Use of stable isotopically labeled benzene to evaluate environmental exposures.
MedLine Citation:
PMID:  12973367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of stable, isotopically labeled compounds in controlled exposure experiments at environmentally relevant levels allows for the distinguishing of urinary metabolites associated with known exposure from background levels generally present in the urine. Exposures of volunteers to (13)C-benzene for 2 h at 40+/-10 p.p.b. were conducted after obtaining informed consent, and urinary phenol, catechol, hydroquinone and trans,trans- muconic acid were measured. Each isotopically labeled urinary metabolite was determined in the presence of significantly higher concentrations of the unlabeled metabolite. Following exposure, free and acid hydrolyzed phenol, acid hydrolyzed catechol and hydroquinone, and free trans,trans-muconic acid were determined by GC/MS. The percentage of trans,trans-muconic acid excreted was higher than reported following exposure at occupational levels. The use of isotopically labeled compounds has the potential to investigate the metabolism of common environmental contaminants for validation of toxicokinetic models and improve risk extrapolation from high concentration occupational exposures and animal studies to environmentally relevant pollutant levels.
Authors:
Clifford P Weisel; Seongsoo Park; Heesoo Pyo; Krishnan Mohan; Gisela Witz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of exposure analysis and environmental epidemiology     Volume:  13     ISSN:  1053-4245     ISO Abbreviation:  J Expo Anal Environ Epidemiol     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-15     Completed Date:  2004-03-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9111438     Medline TA:  J Expo Anal Environ Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  393-402     Citation Subset:  IM    
Affiliation:
Environmental & Occupational Health Sciences Institute and Department of Environmental & Community Medicine, Robert Wood Johnson Medical School/University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA. weisel@eohsi.rutgers.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Benzene / analysis*,  pharmacokinetics*
Biological Markers / urine
Carbon Isotopes / diagnostic use
Catechols / urine
Environmental Exposure / analysis*
Female
Gas Chromatography-Mass Spectrometry
Humans
Hydroquinones / urine
Male
Middle Aged
Phenol / urine
Sorbic Acid / analogs & derivatives*,  analysis
Grant Support
ID/Acronym/Agency:
ES02558/ES/NIEHS NIH HHS; ES05022/ES/NIEHS NIH HHS; ES09676/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Carbon Isotopes; 0/Catechols; 0/Hydroquinones; 108-95-2/Phenol; 110-44-1/Sorbic Acid; 120-80-9/catechol; 123-31-9/hydroquinone; 505-70-4/muconic acid; 71-43-2/Benzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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