| Use of sorption promoters to increase systemic absorption of coumarin from transdermal drug delivery systems. | |
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MedLine Citation:
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PMID: 3245850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In previous communications it was shown that coumarin is transdermally well absorbed. Increasing the application area for a coumarin ointment from 5 cm2 to 30 cm2, the absolute bioavailability increases from 8.6% to 66%. Using a transdermal drug delivery system (TDDS) based on an elastomer matrix, the absolute bioavailability was 21.9%. By selecting a proper sorption promoter (Labrafil), the absolute bioavailability increased to 71%. No correlation was found between tlag, flux or amount permeated obtained from ex vivo flux measurements, and the in vivo parameters Cmax and AUC. Whereas the bioavailability of a large area application of coumarin ointment is practically the same as with a small TDDS, the latter one is preferred to maintain a therapeutic concentration over a 24 h or 48 h period. |
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Authors:
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W A Ritschel; J K Barkhaus |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 38 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-06-02 Completed Date: 1989-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1774-7 Citation Subset: IM |
Affiliation:
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Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, OH. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Animals Biological Availability Coumarins / administration & dosage, pharmacokinetics* Diffusion Drug Compounding Rats Rats, Inbred Strains Skin Absorption Solubility |
| Chemical | |
Reg. No./Substance:
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0/Coumarins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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