| Use of sequentially administered stable lead isotopes to investigate changes in blood lead during pregnancy in a nonhuman primate (Macaca fascicularis). | |
| | |
MedLine Citation:
|
PMID: 9344623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of pregnancy on the flux of lead from maternal bone were investigated in five females from a unique colony of cynomolgus monkeys (Macaca fascicularis) which had been dosed orally with lead (approximately 1100-1300 microg Pb/kg body wt) throughout their lives (about 14 years). Through the use of stable lead isotopes 204Pb, 206Pb, and 207Pb, it was possible to differentiate between the lead contributed to blood lead from the skeleton and the lead contributed from the current oral dose. Blood samples and bone biopsy samples taken before, during, and after pregnancy were analyzed for lead (total and stable isotope ratios) by thermal ionization mass spectrometry. Through the use of end-member unmixing equations, the contribution to blood of lead from maternal bone during pregnancy was estimated and compared to the contribution of lead from maternal bone before pregnancy. A 29 to 56% decrease in bone lead mobilization in the first trimester was followed by an increase in the second and third trimesters, up to 44% over baseline levels. In one monkey, the third-trimester increase did not reach baseline levels. In a single low-lead monkey, a similar decrease in the first trimester was followed by a 60% increase in the third trimester, indicating that a similar pattern of flux is seen over a wide range of lead concentrations. Analysis of maternal bone and fetal bone, brain, liver, and kidneys confirmed a substantial transplacental transfer of endogenous lead. Lead concentrations in fetal bone often exceeded maternal bone lead concentrations. From 7 to 39% of the lead in the fetal skeleton originated from the maternal skeleton. |
| | |
Authors:
|
C A Franklin; M J Inskip; C L Baccanale; C M Edwards; W I Manton; E Edwards; E J O'flaherty |
Related Documents
:
|
21635813 - Maternal endometrial oedema may increase perinatal mortality of cloned and transgenic p... 22254593 - Phase plane based identification of fetal heart rate patterns. 1645853 - Different roles for the pituitary and adrenal cortex in the control of enkephalin pepti... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Fundamental and applied toxicology : official journal of the Society of Toxicology Volume: 39 ISSN: 0272-0590 ISO Abbreviation: Fundam Appl Toxicol Publication Date: 1997 Oct |
Date Detail:
|
Created Date: 1997-12-16 Completed Date: 1997-12-16 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8200838 Medline TA: Fundam Appl Toxicol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 109-19 Citation Subset: IM |
Copyright Information:
|
Copyright 1997 Society of Toxicology. |
Affiliation:
|
Pest Management Regulatory Agency, Health Canada, Ottawa, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Brain / embryology, metabolism Female Femur / embryology, metabolism Gestational Age Isotopes Kidney / embryology, metabolism Lead / administration & dosage, blood* Liver / embryology, metabolism Macaca fascicularis Male Mass Spectrometry Pregnancy Pregnancy, Animal / blood* Tibia / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
N01-ES-05285/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Isotopes; 7439-92-1/Lead |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Coincubation of rat renal proximal tubules with hepatic subcellular fractions potentiates the effect...
Next Document: Physiologically based pharmacokinetics and the dermal absorption of 2-butoxyethanol vapor by humans.