| Use of sequential teboroxime imaging for the detection of coronary artery occlusion and reperfusion in ischemic and infarcted myocardium. | |
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MedLine Citation:
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PMID: 8154415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nine Yorkshire pigs underwent coronary artery occlusion followed by 2 hours of reperfusion. In five pigs (group A) the occlusion time was 15 minutes and in four pigs (group B) the occlusion time was 1 hour. Teboroxime was administered and images were acquired at baseline, and following occlusion and reperfusion. Infarct size was determined by triphenyl tetrazolium staining. Normalized regional myocardial blood flow, as determined by radio-labeled microspheres, was 0.26 +/- 0.09 following occlusion and 0.83 +/- 0.07 following reperfusion (p < 0.01). Significant differences were found between the defect/normal scan ratios on the baseline and occlusion scans (1.0 +/- 0.03 vs 0.54 +/- 0.10; p < 0.01) and between the occlusion and reperfusion scans (0.54 +/- 0.10 vs 0.97 +/- 0.17; p < 0.01). This is the first study to demonstrate that rapid sequential teboroxime imaging can detect acute coronary occlusion and reperfusion to both ischemic and infarcted myocardium. Teboroxime may be an excellent tracer for the early evaluation of infarct artery patency in patients receiving thrombolytic therapy. |
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Authors:
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L I Heller; B J Villegas; B H Weiner; B A McSherry; S T Dahlberg; J A Leppo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American heart journal Volume: 127 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-12 Completed Date: 1994-05-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 779-85 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Massachusetts Medical Center, Worcester 01655. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Circulation* Coronary Disease / radionuclide imaging* Coronary Vessels / radionuclide imaging Heart / radionuclide imaging Myocardial Infarction / physiopathology, radionuclide imaging* Myocardial Ischemia / radionuclide imaging Organotechnetium Compounds / diagnostic use* Oximes / diagnostic use* Swine |
| Grant Support | |
ID/Acronym/Agency:
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HL25199/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds; 0/Oximes; 104716-22-5/technetium Tc 99m teboroxime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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