Document Detail


Use of a sentinel host system to study the questing behavior of Ixodes spinipalpis and its role in the transmission of Borrelia bissettii, human granulocytic ehrlichiosis, and Babesia microti.
MedLine Citation:
PMID:  11693872     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ixodes spinipalpis maintains Borrelia bissettii spirochetes in Colorado in a cycle involving wood rats and deer mice. This tick has been described as nidicolous, remaining either attached to its rodent hosts or in the rodent nest. Nidicolous ticks pose little risk of pathogen transmission to humans if they do not actively quest for hosts. To investigate the questing potential of I. spinipalpis, sentinel mice were placed in an area where I. spinipalpis had been commonly found on wood rats and deer mice. Concurrently, wild rodent populations were trapped and analyzed for Lyme disease spirochetes, the agent of human granulocytic ehrlichiosis (aoHGE), and Babesia microti. A total of 122 I. spinipalpis larvae and 10 nymphs were found on 19% of 244 sentinel mice. In addition, 4 sentinel mice became infested with Malaraeus telchinus or Orchopeas neotomae fleas. Questing I. spinipalpis were positively associated with woody shrubs and negatively associated with sunny and grassy areas. Four sentinel mice became infected with aoHGE after having been fed upon only by I. spinipalpis larvae. One sentinel mouse became infected with B. bissettii after having an I. spinipalpis nymph feed on it, and one sentinel mouse became coinfected with aoHGE and B. bissettii after it was fed upon by a single I. spinipalpis nymph. These sentinel mouse conversions suggest the possibility that the aoHGE is transovarially transmitted by I. spinipalpis, and that I. spinipalpis is capable of simultaneously transmitting B. bissettii and the aoHGE. The findings that I. spinipalpis quest away from rodent nests and will attach to and infect sentinel mice may be of public health importance. It suggests the potential transmission of the agents of human granulocytic ehrlichiosis and Lyme disease to other hosts by I. spinipalpis, in regions of the western United States where Ixodes pacificus is not found.
Authors:
T R Burkot; G O Maupin; B S Schneider; C Denatale; C M Happ; J S Rutherford; N S Zeidner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  65     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  AIM; IM    
Affiliation:
Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachnid Vectors / microbiology*,  parasitology
Babesia / physiology
Babesiosis / parasitology*
Borrelia / physiology
Borrelia Infections / transmission*
Colorado
Disease Reservoirs
Ehrlichia / physiology
Ehrlichiosis / transmission*
Granulocytes
Host-Parasite Interactions
Humans
Ixodes / microbiology*,  parasitology
Lyme Disease / transmission
Mice
Muridae / parasitology*
Nymph / parasitology
Public Health
Rats
Rodent Diseases / parasitology,  transmission
Seasons
Specific Pathogen-Free Organisms
Tick Infestations / parasitology,  veterinary
Zoonoses

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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