| Use of reprogrammed cells to identify therapy for respiratory papillomatosis. | |
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MedLine Citation:
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PMID: 23013073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. We used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. Analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (HPV-11) genome, whereas the pulmonary tumor cells contained a 10.4-kb genome. The increased size of the latter viral genome was due to duplication of the promoter and oncogene regions. Chemosensitivity testing identified vorinostat as a potential therapeutic agent. At 3 months after treatment initiation, tumor sizes had stabilized, with durable effects at 15 months. |
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Authors:
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Hang Yuan; Scott Myers; Jingang Wang; Dan Zhou; Jennifer A Woo; Bhaskar Kallakury; Andrew Ju; Michael Bazylewicz; Yvonne M Carter; Christopher Albanese; Nazaneen Grant; Aziza Shad; Anatoly Dritschilo; Xuefeng Liu; Richard Schlegel |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The New England journal of medicine Volume: 367 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-09-27 Completed Date: 2012-10-11 Revised Date: 2012-12-27 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 1220-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Georgetown University Medical Center, Washington, DC 20057, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use* Cells, Cultured DNA, Viral / isolation & purification Gene Expression Genome, Viral Human papillomavirus 11 / genetics Humans Hydroxamic Acids / therapeutic use* Laryngeal Neoplasms / surgery, virology Lung / cytology* Lung Neoplasms / drug therapy, pathology*, virology Male Mutation Papillomavirus Infections / complications, drug therapy*, pathology, surgery RNA, Messenger / metabolism RNA, Viral / analysis Respiratory Tract Infections / complications, drug therapy*, pathology, surgery Tumor Cells, Cultured Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 OD011168/OD/NIH HHS; R01 OD011168/OD/NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/DNA, Viral; 0/Hydroxamic Acids; 0/RNA, Messenger; 0/RNA, Viral; 149647-78-9/vorinostat |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 2012 Dec 27;367(26):2553-4; author reply 2554
[PMID:
23268676
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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