Document Detail


Use of reprogrammed cells to identify therapy for respiratory papillomatosis.
MedLine Citation:
PMID:  23013073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A patient with a 20-year history of recurrent respiratory papillomatosis had progressive, bilateral tumor invasion of the lung parenchyma. We used conditional reprogramming to generate cell cultures from the patient's normal and tumorous lung tissue. Analysis revealed that the laryngeal tumor cells contained a wild-type 7.9-kb human papillomavirus virus type 11 (HPV-11) genome, whereas the pulmonary tumor cells contained a 10.4-kb genome. The increased size of the latter viral genome was due to duplication of the promoter and oncogene regions. Chemosensitivity testing identified vorinostat as a potential therapeutic agent. At 3 months after treatment initiation, tumor sizes had stabilized, with durable effects at 15 months.
Authors:
Hang Yuan; Scott Myers; Jingang Wang; Dan Zhou; Jennifer A Woo; Bhaskar Kallakury; Andrew Ju; Michael Bazylewicz; Yvonne M Carter; Christopher Albanese; Nazaneen Grant; Aziza Shad; Anatoly Dritschilo; Xuefeng Liu; Richard Schlegel
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The New England journal of medicine     Volume:  367     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-27     Completed Date:  2012-10-11     Revised Date:  2012-12-27    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1220-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Georgetown University Medical Center, Washington, DC 20057, USA.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / therapeutic use*
Cells, Cultured
DNA, Viral / isolation & purification
Gene Expression
Genome, Viral
Human papillomavirus 11 / genetics
Humans
Hydroxamic Acids / therapeutic use*
Laryngeal Neoplasms / surgery,  virology
Lung / cytology*
Lung Neoplasms / drug therapy,  pathology*,  virology
Male
Mutation
Papillomavirus Infections / complications,  drug therapy*,  pathology,  surgery
RNA, Messenger / metabolism
RNA, Viral / analysis
Respiratory Tract Infections / complications,  drug therapy*,  pathology,  surgery
Tumor Cells, Cultured
Young Adult
Grant Support
ID/Acronym/Agency:
R01 OD011168/OD/NIH HHS; R01 OD011168/OD/NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/DNA, Viral; 0/Hydroxamic Acids; 0/RNA, Messenger; 0/RNA, Viral; 149647-78-9/vorinostat
Comments/Corrections
Comment In:
N Engl J Med. 2012 Dec 27;367(26):2553-4; author reply 2554   [PMID:  23268676 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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